Special Issue "Cytogenetic and Molecular Effects of Marine Compounds"
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (15 July 2013)
Prof. Dr. Blanca Laffon
Toxicology Unit, Psychobiology Department, University of A Coruña, Edificio de Servicios Centrales de Investigación, Campus Elviña s/n, 15071 A Coruña, Spain
Phone: +981 167 000 4657 2680
The oceans sustain a huge variety of fish, marine mammals, invertebrates, macro- and microalgae, cyanobacteria and other microorganisms. The level of diversity is much higher than it is on land; it is only partly explored, and that gives an essentially limitless source of structurally unique chemical compounds with potential biological activity.
A great percentage of all new drugs introduced in the market come from natural substances. Many of these drugs and related products, such as functional foods and nutraceuticals, have been derived from marine organisms, showing that despite increasingly sophisticated and effectiveness methods to design and produce drugs in the lab, Mother Nature is still the best pharmacological factory. Thus, many marine compounds are being studied for biomedical activity (anticoagulant, antibacterial, antiviral, antifungal, antiprotozoal, anti-inflammatory, anticancer, etc.) as potential pharmaceuticals for the benefit of humankind, yielding important information on their cytogenetic and molecular effects and mechanisms of action.
Marine compounds are also investigated for possible cosmetic, agrochemical, food processing, material and biosensor applications. So, for all substances that will potentially be in contact with humans and released into the environment, there is an impelling need to reveal their possible interactions with cell compounds and eventually their effects on human health and on the ecosystems.
Besides, other marine compounds are toxic for the human beings. This is the case of the marine toxins, a wide group of substances that can contaminate seafood, mainly shellfish and fish, resulting in food poisoning. Although the vast effects for human health are generally well known, the molecular basis of their action mechanisms have not been always described in detail.
Therefore, the main objective of this special issue of Marine Drugs is to compile studies on the effects of marine compounds, both from the cytogenetic and the molecular points of view.
Prof. Dr. Blanca Laffon
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed Open Access monthly journal published by MDPI.
- marine compounds
- marine drugs
- marine toxins
- molecular effects
- molecular targets
- molecular interactions
- gene expression
- protein expression
- DNA repair
- cytotoxicity Ecotoxicity
Review: Bivalve Omics: State of the Art and Potential Applications for the Biomonitoring of Harmful Marine Compounds
Mar. Drugs 2013, 11(11), 4370-4389; doi:10.3390/md11114370
Received: 10 July 2013; in revised form: 27 September 2013 / Accepted: 9 October 2013 / Published: 1 November 2013| Cited by 2 | PDF Full-text (964 KB) | HTML Full-text | XML Full-text
Mar. Drugs 2013, 11(11), 4328-4349; doi:10.3390/md11114328
Received: 15 July 2013; in revised form: 8 October 2013 / Accepted: 23 October 2013 / Published: 31 October 2013| PDF Full-text (394 KB) | HTML Full-text | XML Full-text
Article: Reporter Dyes Demonstrate Functional Expression of Multidrug Resistance Proteins in the Marine Flatworm Macrostomum lignano: The Sponge-Derived Dye Ageladine A Is Not a Substrate of These Transporters
Mar. Drugs 2013, 11(10), 3951-3969; doi:10.3390/md11103951
Received: 10 July 2013; in revised form: 26 August 2013 / Accepted: 27 September 2013 / Published: 16 October 2013| PDF Full-text (802 KB) | HTML Full-text | XML Full-text
Review: Microcystin-LR and Cylindrospermopsin Induced Alterations in Chromatin Organization of Plant Cells
Mar. Drugs 2013, 11(10), 3689-3717; doi:10.3390/md11103689
Received: 17 June 2013; in revised form: 19 August 2013 / Accepted: 22 August 2013 / Published: 30 September 2013| PDF Full-text (1014 KB) | HTML Full-text | XML Full-text
Review: Advances in the Study of the Structures and Bioactivities of Metabolites Isolated from Mangrove-Derived Fungi in the South China Sea
Mar. Drugs 2013, 11(10), 3601-3616; doi:10.3390/md11103601
Received: 1 August 2013; in revised form: 21 August 2013 / Accepted: 3 September 2013 / Published: 30 September 2013| PDF Full-text (1358 KB) | HTML Full-text | XML Full-text
Article: Pharmacological Studies of Tentacle Extract from the Jellyfish Cyanea capillata in Isolated Rat Aorta
Mar. Drugs 2013, 11(9), 3335-3349; doi:10.3390/md11093335
Received: 3 July 2013; in revised form: 21 August 2013 / Accepted: 23 August 2013 / Published: 30 August 2013| Cited by 1 | PDF Full-text (772 KB) | HTML Full-text | XML Full-text
Review: Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates
Mar. Drugs 2013, 11(8), 2829-2845; doi:10.3390/md11082829
Received: 10 July 2013; in revised form: 30 July 2013 / Accepted: 1 August 2013 / Published: 9 August 2013| Cited by 1 | PDF Full-text (770 KB) | HTML Full-text | XML Full-text
Last update: 18 January 2013