Sleep Disorders and Epilepsy

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 3067

Special Issue Editor


E-Mail Website
Guest Editor
Chair, Department of Neurology, School of Medicine, Kaohsiung Medical University and Hospital, Kaohsiung, Taiwan
Interests: sleep disorders; epilepsy; polysomnography; video EEG monitoring

Special Issue Information

Dear Colleagues,

Sleep disorders and epilepsy reflect three levels of brain dysfunction in terms of cerebral cortex, the hypothalamus, and brainstem. Sleep disturbance is common in patients with epilepsy. Sleep deprivation and disruption of rapid-eye-movement sleep might promote seizures. Sleep-disordered breathing, which is the most common and a treatable sleep disorder, might be associated with seizure recurrence and medically refractory epilepsy. The differential diagnosis of nocturnal paroxysmal events which cover both sleep-related epilepsy, sleep-related movement disorders, and parasomnias is important. This Special Issue invites all kinds of clinical and basic research in the interface between sleep disorders and epilepsy.

Dr. Chung-Yao Hsu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sleep
  • sleep architecture
  • sleep disorders
  • sleep-disordered breathing
  • sleep apnea
  • parasomnia
  • epilepsy
  • sleep-related epilepsy
  • sleep-related movement disorders
  • paroxysmal disorders

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 14434 KiB  
Article
Spike-Wave Seizures, NREM Sleep and Micro-Arousals in WAG/Rij Rats with Genetic Predisposition to Absence Epilepsy: Developmental Aspects
by Maxim Zhuravlev, Anastasiya Runnova, Kirill Smirnov and Evgenia Sitnikova
Life 2022, 12(4), 576; https://doi.org/10.3390/life12040576 - 12 Apr 2022
Cited by 6 | Viewed by 2518
Abstract
The current study was done in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats, which are genetically prone to develop spontaneous spike-wave discharges (SWDs) and are widely used as a genetic model of absence epilepsy. Here, we examined functional links between sleep and spike-wave epilepsy [...] Read more.
The current study was done in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats, which are genetically prone to develop spontaneous spike-wave discharges (SWDs) and are widely used as a genetic model of absence epilepsy. Here, we examined functional links between sleep and spike-wave epilepsy in aging WAG/Rij rats using advanced techniques of EEG analysis. SWDs, periods of NREM sleep and micro-arousals were automatically detected in three-channel epidural EEG recorded in freely moving WAG/Rij rats consequently at the age 5, 7 and 9 months. We characterized the developmental profile of spike-wave epilepsy in drug-naïve WAG/Rij rats and defined three epi-phenotypes—severe, mild and minor epilepsy. Age-related changes of SWDs were associated with changes in NREM sleep. Several signs of NREM sleep fragmentation were defined in epileptic WAG/Rij rats. It seems that spike-wave epilepsy per se promotes micro-arousals during NREM sleep. However, subjects with a higher number of micro-arousals (and NREM sleep episodes) at the age of 5 months were characterized by a reduction of SWDs between 5 and 7 months of age. Full article
(This article belongs to the Special Issue Sleep Disorders and Epilepsy)
Show Figures

Figure 1

Back to TopTop