Protein Phosphorylation: Mechanism and Regulation
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Proteins and Proteomics".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 10877
Special Issue Editor
Special Issue Information
Dear Colleagues,
Reversible protein phosphorylation is one of the most important post-translational modifications, which plays essential roles in biological activities, such as gene expression, cell proliferation, signal transduction, etc. About one-third of proteins are presumed to be phosphorylated in eucaryote. Phosphorylation modifies enzymatic activity, protein structure, interaction, and localization. More elaborate and complicated regulation networks have been revealed to control the birth and death of cells since the discovery of protein phosphorylation. ATP-dependent protein phosphorylation is closely regulated by energy metabolism and, in turn, it also regulates energy metabolism through changing enzyme/protein functions. Mitochondria is famous as an energy house and it may carry out apoptosis when cells undergo stress. Protein phosphorylation performs critical regulatory roles in this complex process through altering protein behavior. In addition, the inhibitors or activators of protein kinases or phosphatases are always used to regulate signal transduction, such as the well-understood mTOR and MAPK signaling pathways. As the development of mass spectrometric technology, proteins are identified with more multiply modifications besides phosphorylation. The positive or negative crosstalk between protein phosphorylation and other post-translational modifications adds more complexity to investigate cellular activities.
This Special Issue aims to communicate latest research outcomes from various fields on the roles of protein phosphorylation in the regulation of protein functions. High-quality papers within the journal’s scope, including original research reviews and articles, are welcome.
Dr. Xin Li
Guest Editor
Manuscript Submission Information
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Keywords
- protein phosphorylation
- energy metabolism
- protein post-translational modifications crosstalk
- apoptosis
- protein kinase