Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.7
3.2
Journals
Life
Special Issues
Research Updates in Neurodevelopmental Disorders
share announcement

Research Updates in Neurodevelopmental Disorders

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (14 July 2023) | Viewed by 8222

Special Issue Editors

Dr. Panagiota Pervanidou

E-Mail Website
Guest Editor
Developmental and Behavioral Pediatrics, First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, “Aghia Sophia” Children’s Hospital, 11527 Athens, Greece
Interests: neurodevelopment; children; autism spectrum disorder; ADHD; early life stress; parenting; childhood obesity
Special Issues, Collections and Topics in MDPI journals
Dr. Artemios Pehlivanidis

E-Mail Website
Guest Editor
First Department of Psychiatry, Adult Neurodevelopmental Disorders Unit, Eginition Hospital, National and Kapodistrian University of Athens, 11518 Athens, Greece
Interests: psychiatry; neurodevelopmental disorders; autism; ADHD; cognitive psychotherapy
Dr. Katerina Papanikolaou

E-Mail Website
Guest Editor
Department of Child Psychiatry, Medical School, Aghia Sophia Children’s Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: child psychiatry; neurodevelopmental disorders; autism; cognitive psychotherapy; childhood obesity

Special Issue Information

Dear Colleagues,

Neurodevelopmental disorders (NDs) are a group of conditions that affect the development of the central nervous system, causing difficulties in behaviour and cognitive, social, and emotional functioning. NDs usually emerge during the early stages of development, and are mostly present in toddlers, children, and adolescents, but continue to persist into adulthood, or may be diagnosed later, in adolescence and adulthood. The conditions that are classified as NDs include the following: intellectual disability, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), communication disorders, motor disorders, and learning disorders. They are all heterogeneous conditions, with a broad phenotypic variation and high rates of overlapping symptoms and comorbidity. Prematurity, fetal growth restriction, and prenatal influences, as well as genetic conditions, are directly related to neurodevelopmental outcomes. NDs are quite prevalent in the general population, with an estimated rate of approximately 17%; autism, specifically, presents an increasing prevalence: from 1 in 50 children in 2000 to 1 in 44 children today, according to the CDC.

This Special Issue highlights recent advances in the understanding and monitoring of neurodevelopmental disorders throughout the lifespan. It is mainly focused on neurobiological and genetic factors related to NDs, prenatal conditions that affect neurodevelopment, but also clinical, diagnostic, and therapeutic perspectives. The Special Issue welcomes research and review articles.

Dr. Panagiota Pervanidou
Dr. Artemios Pehlivanidis
Dr. Katerina Papanikolaou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodevelopment
  • autism
  • ADHD
  • intellectual disability
  • learning disorder
  • communication disorder
  • motor disorder
  • neurodevelopmental disorders
  • clinical genetics
  • children
  • adults

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

13 pages, 740 KiB  
Article
Biochemical and Microbiological Aspects of the Oral Cavity of Children and Young People with Neurological Impairment and Oropharyngeal Dysphagia
by Janaina Costa Marangon Duarte, Isabela Bazzo Costa, Daniel de Bortoli Teixeira, Luiz Fernando Fregatto, Claudemir Gregorio Mendes, Aline Maria Noli Mascarin, Salum Bueno da Silveira Junior, Bianca Eduarda Baptistella Mesquita Serva, Livia Picchi Comar, Roberta Gonçalves da Silva, Daniela Vieira Buchaim, Rogerio Leone Buchaim, Eduardo Federighi Baisi Chagas, Francisco Agostinho Junior and Paula Cristina Cola
Life 2023, 13(6), 1342; https://doi.org/10.3390/life13061342 - 08 Jun 2023
Viewed by 1195
Abstract
The components and the salivary flow have a direct influence on the composition of the oral microbiota of children and young people with oropharyngeal dysphagia, and studies have already demonstrated the excessive accumulation of supragingival dental calculus in individuals with enteral nutrition. This [...] Read more.
The components and the salivary flow have a direct influence on the composition of the oral microbiota of children and young people with oropharyngeal dysphagia, and studies have already demonstrated the excessive accumulation of supragingival dental calculus in individuals with enteral nutrition. This study aimed to compare the oral hygiene, biochemical, and microbiological aspects of the oral cavity of children and young people with neurological impairment and oropharyngeal dysphagia. Forty children and young people with neurological impairment and oropharyngeal dysphagia were enrolled and divided into two groups: group I, encompassing 20 participants fed via gastrostomy; and group II, encompassing 20 participants fed via the oral route. Oral hygiene and salivary pH and flow were assessed, and a polymerase chain reaction was performed to evaluate the messenger RNA expressions of Porphyromonas gingivalis, Tanerella forsythia, and Treponema denticola. In groups I and II, the mean Oral Hygiene Index—Simplified scores were 4 and 2, respectively, showing a significant difference; the mean Calculus Index scores were 2 and 0, respectively, showing a significant difference; and the mean pH was 7.5 and 6.0, respectively, showing a significant difference. Bacterial analysis indicated no association between the two groups. It can be concluded that children and young people who use gastrostomy had a poorer oral hygiene, greater dental calculus deposition, and higher salivary pH. The saliva of patients in both groups contained Porphyromonas gingivalis, Tanerella forsythia, and Treponema denticola. Full article
(This article belongs to the Special Issue Research Updates in Neurodevelopmental Disorders)
►▼ Show Figures

Figure 1

13 pages, 1112 KiB  
Article
Executive Function and Working Memory Deficits in Females with Fragile X Premutation
by Osnat Segal, Tamar Kowal, Yonit Banet-Levi and Lidia V. Gabis
Life 2023, 13(3), 813; https://doi.org/10.3390/life13030813 - 17 Mar 2023
Cited by 2 | Viewed by 1491
Abstract
The Fragile X premutation is a genetic instability of the FMR1 gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were [...] Read more.
The Fragile X premutation is a genetic instability of the FMR1 gene caused by 55–199 recurrences of the CGG sequence, whereas there are only 7–54 repeats of the CGG sequence in the normal condition. While males with the premutation of Fragile X were found to have difficulties in executive functions and working memory, little data have been collected on females. This study is among the first to address executive functions and phonological memory in females with the Fragile X premutation. Twenty-three female carriers aged 20–55 years and twelve non carrier females matched in age and levels of education (in years) participated in this study. Executive functions and phonological memory were assessed using the self-report questionnaire The Behavior Rating Inventory of Executive Function (BRIEF) and behavioral measures (nonword repetitions, forward and backward digit span). Females who were carriers of the premutation of the FMR1 gene reported less efficient executive functions in the BRIEF questionnaire compared to the control group. In addition, a relationship was found between the number of repetitions on the CGG sequence of nucleotides, nonword repetitions, and forward digit span. The findings suggest that the premutation of Fragile X in females affects their performance of executive functions and may have impact on everyday functioning. Full article
(This article belongs to the Special Issue Research Updates in Neurodevelopmental Disorders)
►▼ Show Figures

Figure 1

Other

Jump to: Research

11 pages, 2373 KiB  
Brief Report
Sex and Age-Dependent Olfactory Memory Dysfunction in ADHD Model Mice
by Jae-Sang Sim, Won-Seok Lee and Bo-Eun Yoon
Life 2023, 13(3), 686; https://doi.org/10.3390/life13030686 - 02 Mar 2023
Cited by 1 | Viewed by 2038
Abstract
ADHD is a typical neurodevelopmental disorder with a high prevalence rate. NSCs in the subventricular zone (SVZ) are closely related to neurodevelopmental disorder and can affect olfactory function by neurogenesis and migratory route. Although olfactory dysfunction is one of the symptoms of ADHD, [...] Read more.
ADHD is a typical neurodevelopmental disorder with a high prevalence rate. NSCs in the subventricular zone (SVZ) are closely related to neurodevelopmental disorder and can affect olfactory function by neurogenesis and migratory route. Although olfactory dysfunction is one of the symptoms of ADHD, the relevance of cells in the olfactory bulb derived from NSCs has not been studied. Therefore, we investigated olfactory memory and NSCs in Git1-deficient mice, under the ADHD model. Interestingly, only adult male G protein-coupled receptor kinase-interacting protein-1 (GIT1)-deficient (+/−, HE) mice showed impaired olfactory memory, suggesting sex and age dependence. We performed adult NSCs culture from the SVZ and observed distinct cell population in both sex and genotype. Taken together, our study suggests that the altered differentiation of NSCs in GIT1+/− mice can contribute to olfactory dysfunction in ADHD. Full article
(This article belongs to the Special Issue Research Updates in Neurodevelopmental Disorders)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop