Personalized Medicine in the ICU—2nd Edition

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Critical Care".

Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 1241

Special Issue Editors


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Guest Editor
Faculty of Medicine, School of Health Sciences, University Hospital of Larissa, University of Thessaly, 41110 Larissa, Greece
Interests: critical care; ARDS; mechanical ventilation; sepsis; hemodynamics; echocardiography; arrythmias; cardiomyopathy; neuromonitoring; MODS; COVID-19
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E-Mail Website
Guest Editor
General University Hospital of Larissa, University of Thessaly Faculty of Medicine, 41110 Larissa, Greece
Interests: ARDS; mechanical ventilation; sepsis; hemodynamics; echocardiography; respiratory muscles; diaphragm; esophageal pressure; neuromonitoring; COVID-19
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Journal of Personalized Medicine has launched a Special Issue on “Personalized Medicine in the ICU—2nd Edition”.

Critical care medicine deals with the most vulnerable patients—those who are critically ill. Pathophysiologic mechanisms of disease and the responses to those diseases, monitoring issues, and individualized treatment approaches, especially those concerning dosing, are distinct when compared to regular patients, as well as varying considerably between critical care patients. Critical care departments hospitalize patients with a wide diversity of diseases, all of which require different management approaches (neurosurgical, thoracic-surgical, general surgical, medical, COVID-19 patients).

Patients present with great variations in clinical presentation and often warrant personalization of treatments to fit their needs.

In this Special Issue, we encourage submissions concerning critically ill patients, covering the whole spectrum of patients admitted to the intensive care unit: airway disease, ventilatory management, acute respiratory failure, hemodynamics, acute cardiomyopathies, point of care ultrasonography, acute kidney injury, renal replacement therapies, nutrition, sepsis management, and antibiotics.

In relation to this, we are calling for review articles and original contributions covering all aspects of how personalized medicine can improve critically ill patients’ management within the ICU.

Prof. Dr. Epaminondas Zakynthinos
Dr. Vasiliki Tsolaki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ARDS
  • mechanical ventilation
  • respiratory mechanics
  • monitoring
  • ultrasonography
  • respiratory muscles
  • diaphragm
  • cardiomyopathy
  • arrhythmias
  • sepsis
  • blood stream infections
  • antimicrobial resistance
  • ventilator-associated pneumonia
  • neuromonitoring
  • MODS
  • COVID-19

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Published Papers (1 paper)

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Research

11 pages, 376 KiB  
Article
Prognostic Value of Fibrosis 4 (FIB-4) Index in Sepsis Patients
by Tuna Albayrak and Beyza Yuksel
J. Pers. Med. 2024, 14(5), 531; https://doi.org/10.3390/jpm14050531 - 16 May 2024
Viewed by 951
Abstract
Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has [...] Read more.
Background: Sepsis remains a major health challenge worldwide, characterized by a dysregulated host response to infection, leading to high mortality and morbidity in intensive care units (ICUs). The Fibrosis 4 (FIB-4) index, originally developed to assess liver fibrosis in hepatitis C patients, has recently been explored for its potential prognostic value in sepsis patients. Method: this study retrospectively analyzed 309 sepsis patients admitted to the Internal Medicine and An-aesthesia ICUs between 12 December 2021 and 15 December 2023 to investigate the relationship between FIB-4 levels, the Acute Physiology and Chronic Health Evaluation (APACHE), the Sequential Organ Failure Assessment (SOFA), and clinical outcomes. Results: This study found that higher FIB-4 measurements were statistically significantly associated with increased 28-day mortality, with a cut-off value of 4.9, providing a sensitivity of 54.92% and specificity of 74.25%. Logistic regression analysis indicated that elevated FIB-4 levels were a significant predictor of early mortality, suggesting that the FIB-4 index could serve as a valuable prognostic tool in assessing the severity and prognosis of sepsis patients. Conclusions: by elucidating the potential role of the FIB-4 index in sepsis prognosis, this study contributes to the ongoing efforts to improve risk stratification and enhance patient care in sepsis management. Full article
(This article belongs to the Special Issue Personalized Medicine in the ICU—2nd Edition)
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