Special Issue "Advanced Nanomaterials for Functional Tissue Engineering"

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (30 November 2014)

Special Issue Editors

Guest Editor
Prof. Dr. Akhilesh K. Gaharwar

Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA
Website | E-Mail
Phone: +1-979 458-5540
Interests: nanomaterials; stem cells; functional tissue engineering; biomimetic materials; nanocomposites; gradient structures; protein delivery
Guest Editor
Prof. Dr. Arghya Paul

Department of Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS 66045, USA (from August 2014) Presently at Harvard-MIT Division of Health Sciences and Technology, Cambridge, USA
Website | E-Mail
Interests: biotherapeutic medical implants; hybrid nanomaterials; regenerative medicine; engineered nano delivery systems

Special Issue Information

Dear Colleagues,

Engineering complex tissues that can mimic or stimulate native tissue functions hold enormous promise in treating organ failures resulting from injuries, aging, and diseases. Our inability to mimic complex tissue architectures, and to provide essential cellular microenvironments, are some of the challenges that need to be addressed to control the formation of functional tissues. Designing advanced biotherapeutic materials with controlled physical, chemical, electrical, and biological properties will therefore be beneficial for facilitating the formation of functional tissues.

Among different biomaterials, nanomaterials are one of the potential candidates they can mimic the physical, chemical, electrical, and biological properties of most biological tissues. New applications of the nanomaterials have emerged, particularly in the fields of stem cell engineering, tissue engineering, immunomodulation, cellular and molecular therapies, and cancer research. Most of these applications demand multiple functionalities from the nanomaterials and dynamic interactions between the surrounding matrices and cells. A range of innovations, in polymer chemistry, micro- and nanofabrication technologies, and biomolecular engineering, have pushed the limit for designing composite hydrogel networks with customized functionality. Recent trends also indicate significant and growing interest in developing nanomaterials for various biomedical applications.

This Special Issue seeks contributions regarding new advances in functional nanomaterials with specific emphasis on emerging biomedical applications, such as tissue engineering.  In particular, contributions highlighting some of the emerging trends in designing complex nanomaterials with multiple functionalities are encouraged. We wish to publish original research or review articles in this issue mainly focusing on the following topics:

1. Biofunctional Nanomaterials for Clinical Applications
2. Polymeric Material based Drug or Gene delivery
3. Nanocomposite Hydrogels for Tissue Engineering
4. Bioactive Polymer Coatings for Biomedical Devices
5. Nanotopography and Stem Cells

Dr. Akhilesh K. Gaharwar
Dr. Arghya Paul
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessArticle Differential Cell Adhesion of Breast Cancer Stem Cells on Biomaterial Substrate with Nanotopographical Cues
J. Funct. Biomater. 2015, 6(2), 241-258; doi:10.3390/jfb6020241
Received: 12 February 2015 / Revised: 10 April 2015 / Accepted: 15 April 2015 / Published: 21 April 2015
Cited by 1 | PDF Full-text (3593 KB) | HTML Full-text | XML Full-text | Supplementary Files
Cancer stem cells are speculated to have the capability of self-renewal and re-establishment of tumor heterogeneity, possibly involved in the potential relapse of cancer. CD44+CD24−/lowESA+ cells have been reported to possess tumorigenic properties, and these biomarkers are thought
[...] Read more.
Cancer stem cells are speculated to have the capability of self-renewal and re-establishment of tumor heterogeneity, possibly involved in the potential relapse of cancer. CD44+CD24−/lowESA+ cells have been reported to possess tumorigenic properties, and these biomarkers are thought to be highly expressed in breast cancer stem cells. Cell behavior can be influenced by biomolecular and topographical cues in the natural microenvironment. We hypothesized that different cell populations in breast cancer tissue exhibit different adhesion characteristics on substrates with nanotopography. Adhesion characterizations were performed using human mammary epithelial cells (HMEC), breast cancer cell line MCF7 and primary invasive ductal carcinoma (IDC) cells obtained from patients’ samples, on micro- and nano-patterned poly-L-lactic acid (PLLA) films. Topography demonstrated a significant effect on cell adhesion, and the effect was cell type dependent. Cells showed elongation morphology on gratings. The CD44+CD24−/lowESA+ subpopulation in MCF7 and IDC cells showed preferential adhesion on 350-nm gratings. Flow cytometry analysis showed that 350-nm gratings captured a significantly higher percentage of CD44+CD24 in MCF7. A slightly higher percentage of CD44+CD24−/lowESA+ was captured on the 350-nm gratings, although no significant difference was observed in the CD44+CD24ESA+ in IDC cells across patterns. Taken together, the study demonstrated that the cancer stem cell subpopulation could be enriched using different nanopatterns. The enriched population could subsequently aid in the isolation and characterization of cancer stem cells. Full article
(This article belongs to the Special Issue Advanced Nanomaterials for Functional Tissue Engineering)

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