Special Issue "Mechanics of Cells in Context with Biomaterials"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (30 September 2011)
Dr. Edie C. Goldsmith
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine Columbia, SC 29209, USA
Interests: cardiac fibroblasts; collagen remodeling; extracellular matrix; nanomaterials
With advances in tissue engineering and the goal of developing patches and/or replacement tissues which seamlessly integrate within the native environment, understanding how cells interact with and respond to natural or engineered matrices is crucial for directing cell behavior. Cells are mechanically complex; exhibiting viscoelastic behavior, deforming in response to externally applied mechanical stimuli and regulating dynamic changes cytoskeletal components which contribute to cellular material properties. The mechanical properties of cells are not only dependent upon the cell itself, but also on the local environment. The extracellular matrix, which surrounds cells in their native environment, provides fundamental cues which drive a multitude of cellular functions including differentiation, migration and proliferation. For example, the response of stem cells to the mechanical stiffness of the extracellular matrix has been shown to direct their differentiation down specific lineages. This issue of The Journal of Functional Biomaterials will highlight advances in our understanding of how cells interact with and mechanically probe their environment. Of particular interest are articles which describe methods for assessing cell-matrix interactions or articles dealing with measuring mechanical properties of individual cells or small cell populations. The development of model systems which will allow for the evaluation of environmental factors which effect cell mechanics are also of great interest.
Dr. Edie C. Goldsmith
- cell mechanics
- xxtracellular matrix
- cell adhesion
- atomic force microscopy
Article: Biomechanical Conditioning Enhanced Matrix Synthesis in Nucleus Pulposus Cells Cultured in Agarose Constructs with TGFβ
J. Funct. Biomater. 2012, 3(1), 23-36; doi:10.3390/jfb3010023
Received: 30 November 2011; in revised form: 23 December 2011 / Accepted: 28 December 2011 / Published: 5 January 2012| PDF Full-text (368 KB) | HTML Full-text | XML Full-text
J. Funct. Biomater. 2012, 3(1), 209-224; doi:10.3390/jfb3010209
Received: 22 January 2012; in revised form: 6 March 2012 / Accepted: 13 March 2012 / Published: 22 March 2012| Cited by 2 | PDF Full-text (968 KB) | HTML Full-text | XML Full-text
Article: Effects of Medium and Temperature on Cellular Responses in the Superficial Zone of Hypo-Osmotically Challenged Articular Cartilage
J. Funct. Biomater. 2012, 3(3), 544-555; doi:10.3390/jfb3030544
Received: 26 June 2012; in revised form: 19 July 2012 / Accepted: 27 July 2012 / Published: 9 August 2012| Cited by 1 | PDF Full-text (323 KB) | HTML Full-text | XML Full-text
Last update: 26 February 2014