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Functional Nanoparticles/Nanocomposites for Biomedical Applications
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Functional Nanoparticles/Nanocomposites for Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 4609

Special Issue Editors

Dr. John David Obayemi

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA
Interests: nanoparticles for cancer detection and treatment; implantable biomedical devices for disease treatment; cell-surface interaction; nanomechanical properties of biomedical materials; tissue engineered structures
Dr. Jingjie Hu

E-Mail Website
Guest Editor
Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC, USA
Interests: biomedical and biological materials; mechanics of materials; adhesion; nanomaterials; colloidal gels; vascular embolization devices; targeted therapy

Special Issue Information

Dear Colleagues,

An understanding of the properties of functional nanoparticles/nanocomposite materials is important for the design of theranostic or implantable devices for biomedical applications. To address the challenges with the current treatment techniques associated with the big killer diseases (cardiovascular disease, cancer, etc.), there is a call to develop the next generation of nanoparticle systems in the form of magnetite NPs, gold NPs, viral-based NPs, lipid NPs (LNPs) and nanocomposite structures, with implications for specifically targeting and treating diseases.

These various forms of functional nanoparticle/nanocomposite systems will be explored in this Special Issue, which will include contributions from researchers in multidisciplinary fields with diverse backgrounds in chemistry, physics, biology, materials science and engineering. The research focus in this Special Issue includes, but is not limited to these areas:

  • Nanoparticles for disease diagnosis;
  • Theranostic nanoparticles for cancer detection and treatment;
  • Implantable nanocomposite structures for disease treatment;
  • Polymer nanocomposites for laser-induced heating in cancer treatment.

In each of the above research areas, the papers will focus on the new frontiers in the development of different novel, functional nanoparticle/nanocomposite structures for the targeting and treatment of diseases. Papers will critically explore the development of different functional nanoparticles/nanocomposites, and the characterization, functionalization and interactions with diseases and nondisease cells/tissues under in vitro and in vivo conditions, with implications for biomedical applications.

Dr. John David Obayemi
Dr. Jingjie Hu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • gold nanoparticle
  • polymer nanocomposite
  • magnetic resonance imaging
  • controlled drug delivery
  • theranostics
  • disease detection and treatment

Published Papers (2 papers)

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Research

27 pages, 10055 KiB  
Article
Antifungal Activity of Juglans-regia-Mediated Silver Nanoparticles (AgNPs) against Aspergillus-ochraceus-Induced Toxicity in In Vitro and In Vivo Settings
by Syeda Itrat Zahra Naqvi, Humera Kausar, Arooj Afzal, Mariam Hashim, Huma Mujahid, Maryam Javed, Christophe Hano and Sumaira Anjum
J. Funct. Biomater. 2023, 14(4), 221; https://doi.org/10.3390/jfb14040221 - 14 Apr 2023
Cited by 3 | Viewed by 2549
Abstract
Aflatoxins produced by some species of Aspergillus are considered secondary toxic fungal by-products in feeds and food. Over the past few decades, many experts have focused on preventing the production of aflatoxins by Aspergillus ochraceus and also reducing its toxicity. Applications of various [...] Read more.
Aflatoxins produced by some species of Aspergillus are considered secondary toxic fungal by-products in feeds and food. Over the past few decades, many experts have focused on preventing the production of aflatoxins by Aspergillus ochraceus and also reducing its toxicity. Applications of various nanomaterials in preventing the production of these toxic aflatoxins have received a lot of attention recently. The purpose of this study was to ascertain the protective impact of Juglans-regia-mediated silver nanoparticles (AgNPs) against Aspergillus-ochraceus-induced toxicity by exhibiting strong antifungal activity in in vitro (wheat seeds) and in vivo (Albino rats) settings. For the synthesis of AgNPs, the leaf extract of J. regia enriched with high phenolic (72.68 ± 2.13 mg GAE/g DW) and flavonoid (18.89 ± 0.31 mg QE/g DW) contents was used. Synthesized AgNPs were characterized by various techniques, including TEM, EDX, FT-IR, and XRD, which revealed that the particles were spherical in shape with no agglomeration and fine particle size in the range of 16–20 nm. In vitro antifungal activity of AgNPs was tested on wheat grains by inhibiting the production of toxic aflatoxins by A. ochraceus. According to the results obtained from High-Performance Liquid Chromatography (HPLC) and Thin-Layer Chromatography (TLC) analyses, there was a correlation between the concentration of AgNPs and a decrease in the production of aflatoxin G1, B1, and G2. For in vivo antifungal activity, Albino rats were administrated with different doses of AgNPs in five groups. The results indicated that the feed concentration of 50 µg/kg feed of AgNPs was more effective in improving the disturbed levels of different functional parameters of the liver (alanine transaminase (ALT): 54.0 ± 3.79 U/L and aspartate transaminase (AST): 206 ± 8.69 U/L) and kidney (creatinine 0.49 ± 0.020 U/L and BUN 35.7 ± 1.45 U/L), as well as the lipid profile (LDL 22.3 ± 1.45 U/L and HDL 26.3 ± 2.33 U/L). Furthermore, the histopathological analysis of various organs also revealed that the production of aflatoxins was successfully inhibited by AgNPs. It was concluded that the harmful effects of aflatoxins produced by A. ochraceus can be successfully neutralized by using J. regia-mediated AgNPs. Full article
(This article belongs to the Special Issue Functional Nanoparticles/Nanocomposites for Biomedical Applications)
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13 pages, 22443 KiB  
Article
Acute and Subacute Toxicity Evaluation of Erythrocyte Membrane-Coated Boron Nitride Nanoparticles
by Jinfeng He, Xuanping Zhang, Linhong Liu, Yufei Wang, Renyu Liu, Min Li and Fuping Gao
J. Funct. Biomater. 2023, 14(4), 181; https://doi.org/10.3390/jfb14040181 - 25 Mar 2023
Viewed by 1592
Abstract
Boron nitride nanoparticles have been reported for boron drug delivery. However, its toxicity has not been systematically elucidated. It is necessary to clarify their potential toxicity profile after administration for clinical application. Here, we prepared erythrocyte membrane-coated boron nitride nanoparticles (BN@RBCM). We expect [...] Read more.
Boron nitride nanoparticles have been reported for boron drug delivery. However, its toxicity has not been systematically elucidated. It is necessary to clarify their potential toxicity profile after administration for clinical application. Here, we prepared erythrocyte membrane-coated boron nitride nanoparticles (BN@RBCM). We expect to use them for boron neutron capture therapy (BNCT) in tumors. In this study, we evaluated the acute toxicity and subacute toxicity of BN@RBCM of about 100 nm and determined the half-lethal dose (LD50) of the particles for mice. The results showed that the LD50 of BN@RBCM was 258.94 mg/kg. No remarkable pathological changes by microscopic observation were observed in the treated animals throughout the study period. These results indicate that BN@RBCM has low toxicity and good biocompatibility, which have great potential for biomedical applications. Full article
(This article belongs to the Special Issue Functional Nanoparticles/Nanocomposites for Biomedical Applications)
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