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Modulation of the Immune System in Inflammatory Diseases and Hidradenitis...
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Modulation of the Immune System in Inflammatory Diseases and Hidradenitis Suppurativa

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 2336

Special Issue Editors

Prof. Dr. Falk Georges Bechara

E-Mail Website
Guest Editor
1. International Centre for Hidradenitis Suppurativa/Acne Inversa, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany
2. Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany
Interests: dermatooncology; hidradenitis suppurativa; inflammation; melanoma; endocrinology; skin cancer; surgery; psoriasis; skin
Special Issues, Collections and Topics in MDPI journals
Dr. Nessr Abu Rached

E-Mail Website
Guest Editor Assistant
1. International Centre for Hidradenitis Suppurativa/Acne Inversa, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany
2. Skin Cancer Center, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany
Interests: hidradenitis suppurativa; inflammation; hormones; Merkel cell carcinoma; melanoma; endocrinology; skin cancer; obesity

Special Issue Information

Dear Colleagues,

In inflammatory diseases, a disbalance of the immune system plays a decisive role. An increasing number of drugs, biologics, and vaccines are being developed to modulate the immune system. Many immunomodulators suppress proinflammatory cytokines and stabilise inflammatory diseases. 

For this Special Issue, entitled “Modulation of the Immune System in Inflammatory Diseases and Hidradenitis Suppurativa”, review articles, original articles, and larger case series from various specialities of rheumatology, dermatology, neurology, gastroenterology, endocrinology, virology, pharmacology, and oncology are welcome. Topics will include, but are not limited to, the following areas: 

  • Inflammatory diseases and potential immune system modulators;
  • Newly discovered targets for drugs or vaccines in inflammatory diseases;
  • New insights into the pathogenesis of inflammatory diseases;
  • Potential adverse effects of immunomodulators or treatment response.

You may choose our Joint Special Issue in Vaccines.

Prof. Dr. Falk Georges Bechara
Guest Editor

Dr. Nessr Abu Rached
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hidradenitis suppurativa
  • psoriasis
  • acne inversa
  • inflammatory diseases
  • immune system
  • vaccines
  • multiple sclerosis
  • myositis
  • neuritis
  • Lyme disease
  • Crohn's disease
  • ulcerative colitis
  • axial spondyloarthritis
  • rheumatoid arthritis
  • thyroiditis

Published Papers (2 papers)

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Research

16 pages, 1236 KiB  
Article
Deregulated Long Non-Coding RNAs (lncRNA) as Promising Biomarkers in Hidradenitis Suppurativa
by Uppala Radhakrishna, Uppala Ratnamala, Devendrasinh D. Jhala, Lavanya V. Uppala, Aaren Vedangi, Nazia Saiyed, Maulikkumar Patel, Sushma R. Shah, Rakesh M. Rawal, Gregor B. E. Jemec, Tommaso Mazza, Gianluigi Mazzoccoli and Giovanni Damiani
J. Clin. Med. 2024, 13(10), 3016; https://doi.org/10.3390/jcm13103016 - 20 May 2024
Viewed by 496
Abstract
Background/Objectives: In recent times, epigenetics alterations in Hidradenitis suppurativa (HS) have been explored and exploited translationally to guide investigation of new therapeutic approaches. On the other hand, long noncoding RNAs (LncRNAs), main regulators of the epigenetic status of the human genome, have been [...] Read more.
Background/Objectives: In recent times, epigenetics alterations in Hidradenitis suppurativa (HS) have been explored and exploited translationally to guide investigation of new therapeutic approaches. On the other hand, long noncoding RNAs (LncRNAs), main regulators of the epigenetic status of the human genome, have been scarcely investigated, notwithstanding their potential relevance in broad pathogenesis comprehension. Here, we aim to explore the methylation pattern of lncRNAs in HS. Methods: In this case-control study, 24 HS patients and age-, sex- and BMI-matched controls were analyzed to characterize the methylome of lncRNA genes in peripheral blood cells. Gene ontology analysis (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein–protein interaction (PPI) network, and MCODE analysis were performed. Results: A set of fifteen lncRNA genes exhibited significantly differential methylation patterns, with ten of them showing hypomethylation and five displaying hypermethylation at specific CpG sites. The hypomethylated lncRNA genes were DLEU2, MESTIT1, CASC2, TUG1, KCNQ1DN, PSORS1C3, PCA3, DSCR8, RFPL1S, and PVT1, while the hypermethylated ones were HAR1A, FAM66B, SNHG9, HCG9, and HCP5. These lncRNA genes have been linked to various important biological processes, including cell proliferation, apoptosis, inflammation, chronic inflammatory skin diseases, and wound healing. Their altered methylation status suggests potential roles in regulating these processes, and may contribute to HS pathogenesis and healing mechanisms. Conclusions: This study revealed an interesting dysregulation pattern of definite lncRNAs in the methylome which is linked to both the development of HS and its comorbidities. Epigenetically altered lncRNAs genes could represent useful biomarkers, and could help in guiding innovative treatment strategies. Full article
(This article belongs to the Special Issue Modulation of the Immune System in Inflammatory Diseases and Hidradenitis Suppurativa)
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14 pages, 1489 KiB  
Article
Primary Thyroid Dysfunction Is Prevalent in Hidradenitis Suppurativa and Marked by a Signature of Hypothyroid Graves’ Disease: A Case–Control Study
by Nessr Abu Rached, Johannes W. Dietrich, Lennart Ocker, Daniel R. Quast, Christina Scheel, Thilo Gambichler and Falk G. Bechara
J. Clin. Med. 2023, 12(23), 7490; https://doi.org/10.3390/jcm12237490 - 4 Dec 2023
Viewed by 1586
Abstract
Hidradenitis suppurativa (HS) is a chronic skin disease that can have an association with endocrine disorders. There is conflicting information in the literature regarding the role of the thyroid gland in HS. This study aimed to close this knowledge gap and investigate how [...] Read more.
Hidradenitis suppurativa (HS) is a chronic skin disease that can have an association with endocrine disorders. There is conflicting information in the literature regarding the role of the thyroid gland in HS. This study aimed to close this knowledge gap and investigate how thyroid disease is involved in patients with HS. We carried out a case–control study with a total of 160 patients, of whom 108 were patients with HS and 52 were controls matched for age and sex. Parametric and non-parametric methods were used to analyze the results. We calculated structural parameters of thyroid homeostasis to detect subclinical thyroid disease, non-thyroid disease syndrome and other forms. The severity of HS was not associated with thyroid hormone levels and antibodies (p > 0.05). HS patients with or without hypothyroidism had decreased FT4 levels and a decreased thyroid secretory capacity (SPINA-GT). Titers of TSH receptor autoantibodies (TRAb) were significantly higher in smoking HS patients compared to non-smokers (median: 1.18 vs. 1.08; p = 0.042). The rate of subclinical hypothyroidism was significantly higher in HS patients; thus, subclinical hypothyroidism is an important comorbidity of HS (p < 0.05). Further studies are needed to investigate whether the chronic inflammation of HS is a cause of increased rates of (subclinical) hypothyroidism. Full article
(This article belongs to the Special Issue Modulation of the Immune System in Inflammatory Diseases and Hidradenitis Suppurativa)
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