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Transaction and Interface of Inorganic/Organic Materials and Biological Beings

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 August 2019) | Viewed by 2990

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Guest Editor
Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Umezono, Tsukuba, Ibaraki 305-0045, Japan
Interests: biomineralization; biomaterial; bio-sensing; medical devices
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Special Issue Information

Dear Colleagues,

Based on the demand for clinical medicine related to biomaterials, the importance of immunological control, antimicrobial ability, rapid tissue regeneration and anti-inflammatory effects, etc. is growing. The number of novel biomaterials such as medical combination products, that is, hybrid materials made of drugs and biomaterials, are steadily increasing and are life prolonging. On the other hand, although the research into apatite and titanium is developing well, these materials have unfathomable evolutionary potential because they have high reliability as base materials. The key factor for the application of biomaterials is the transaction between biomaterials and tissues. Ultimately, the interfaces of inorganic/organic materials, the essence of biomaterials, and tissues at various scale levels dominate the applications and value of biomaterials. The interfaces are the frontier of biomaterial applications. Therefore, this Special Issue welcomes not only in vitro/vivo studies, but also chemistry and material science studies with new points of view for biomaterials and biomedical science, because they provide greater understanding of the interfaces of biomaterials and tissues. This Special Issue also welcomes original articles and reviews of the transaction between inorganic/organic materials in biology, such as hard tissue and calculus studies.

Dr. Yuki Sugiura
Guest Editor

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Keywords

  • interface of tissue
  • bahavior of materials in tissue
  • clinical medicine of biomaterials
  • theranostic devices and materials
  • biomineralization
  • tissue regeneration
  • novel biomaterial fabrication
  • highly reliable base materials

Published Papers (1 paper)

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Research

10 pages, 6383 KiB  
Article
Fabrication of Gentamicin-Loaded Hydroxyapatite/Collagen Bone-Like Nanocomposite for Anti-Infection Bone Void Fillers
by Sho Oshima, Taira Sato, Michiyo Honda, Yasushi Suetsugu, Kazuhide Ozeki and Masanori Kikuchi
Int. J. Mol. Sci. 2020, 21(2), 551; https://doi.org/10.3390/ijms21020551 - 15 Jan 2020
Cited by 17 | Viewed by 2668
Abstract
A gentamicin-loaded hydroxyapatite/collagen bone-like nanocomposite (GNT-HAp/Col) was fabricated and evaluated for its absorption–desorption properties, antibacterial efficacy, and cytotoxicity. The hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) powder was mixed with gentamicin sulfate (GNT) in phosphate-buffered saline (PBS) at room temperature. After 6 h mixing, the GNT [...] Read more.
A gentamicin-loaded hydroxyapatite/collagen bone-like nanocomposite (GNT-HAp/Col) was fabricated and evaluated for its absorption–desorption properties, antibacterial efficacy, and cytotoxicity. The hydroxyapatite/collagen bone-like nanocomposite (HAp/Col) powder was mixed with gentamicin sulfate (GNT) in phosphate-buffered saline (PBS) at room temperature. After 6 h mixing, the GNT adsorption in all conditions reached plateau by Langmuir’s isotherm, and maximum GNT adsorption amount was 34 ± 7 μg in 250 μg/mL GNT solution. Saturated GNT-loaded HAp/Col powder of 100 mg was soaked in 10 mL of PBS at 37 °C and released all GNT in 3 days. A shaking culture method for a GNT extraction from the GNT-HAp/Col and an inhibition zone assay for the GNT-HAp/Col compact showed antibacterial efficacy to Escherichia coli (E. coli) at least for 2 days. From the release profile of the GNT from the GNT-HAp/Col powder, antibacterial efficacy would affect E. coli at least for 3 days. Further, no cytotoxicities were observed on MG-63 cells. Thus, the GNT-HAp/Col is a good candidate of bioresorbable anti-infection bone void fillers by prevention initial infections, which is the primary cause of implant-associated infection even for rapid bioresorbable materials. Full article
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