Frontiers in Pentadecapeptide BPC 157

Dear Colleagues,

This special issue deals with a native gastric peptide, resistant and stable in the human gastric juice, membrane stabilizer, counteracting gut-leaky syndrome, the stable gastric pentadecapeptide BPC 157, as a particular target, distinctive from the standard peptide growth factors, with particular molecular pathways involved, controlling VEGF- and NO-pathways. In the early 1990s, pentadecapeptide BPC 157 appeared as a late outbreak of the Robert’s and Szabo’s cytoprotection - organoprotection concept, and previous theoretical/practical breakthrough in the 1980s, and brain-gut axis and gut-brain axis, and as the time went on, with its reported effects, likely most useful confirmation of theory in practical implementation and justification. Against various noxious agents causing direct cell injury, the epithelial and endothelial integrity maintenance in the stomach (cytoprotection) and in the other tissues (organoprotection) was not fully realized with the standard cytoprotective agents (i.e., prostaglandins, before sulfhydrils, CRF, EGF, somatostatin, and dopamine agonists) acting through cytoprotective defensive system. As novel mediator, BPC 157 was coming after the evidenced point of their limited beneficial effects, and NO-system importance widely introduced, but vigorously established interconnection with these important systems (i.e., prostaglandins, dopamine, serotonin, NO). Thereby, BPC 157 therapy has pleiotropic beneficial effect. In addition to the beneficial effect on the entire gastrointestinal tract, and other organs various agents- and/or noxious procedures-induced lesions (liver (cirrhosis), lung, heart, spinal cord and brain), and considerable wound healing (i.e., skin, muscle, tendon, ligament, bone) (and especial wound, i.e., corneal ulcer), it  may include counteraction of the depression-models, schizophrenia positive symptom-models and catalepsy-models. Recently, BPC 157 counteracts the vascular occlusion disturbances and blood pressure disturbances (relieving a Virchow's triad (endothelium lesions, hypercoagulability, stasis) situation) by rapid activation of the collateral vessel pathways.

You may choose our Joint Special Issue in Biomedicines, or Joint Special Issue in Current Issues in Molecular Biology.

Prof. Dr. Predrag Sikiric
Prof. Dr. Sven Seiwerth
Prof. Dr. Gábor Varga
Prof. Dr. Ki-Baik Hahm
Guest Editors

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• Cytoprotection
• Gastric pentadecapeptide BPC 157
• Peptides, Healing
• Tissues lesions
• Blood vessels lesions
• Wounds
• Brain-gut axis
• Inflammation and resolution
• Cancer prevention
• Therapy