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Steroidomics in Physiology and Pathophysiology
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Steroidomics in Physiology and Pathophysiology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 16872

Special Issue Editor

Dr. Martin Hill

E-Mail Website
Guest Editor
Department of Steroid Hormones and Proteohormones, Institute of Endocrinology, Prague, Czech Republic
Interests: steroids; steroidomics; chemometrics; neuroactive steroids; steroids and pregnancy; chromatography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

For decades, steroid analysis has served as an efficient tool for the diagnostics of various endocrinopathies related to the deficiency of steroidogenic enzymes or disturbed regulation of the hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes and for an assessment of predisposition to steroid-related cancers and their timely diagnosis. Whereas mutually intercorrelated steroid alterations may be associated with numerous additional pathologies and with a variety of physiological situations and stages of human life, a complex steroidomic approach based on high throughput platforms in combination with computer-aided data processing is generally highly effective for the investigation of these events. Therefore, this Special Issue, “Steroidomics in Physiology and Pathophysiology”, will embrace original research studies and up-to-date review articles focused on the application of high throughput steroidomic approaches based on advanced analytical platforms for investigation of the molecular mechanisms of various physiological and pathophysiological processes.

Dr. Martin Hill
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • steroidomics
  • physiology
  • pathophysiology
  • diagnosis
  • biomarkers
  • omics platforms

Published Papers (3 papers)

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Research

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42 pages, 451 KiB  
Article
The Role of Steroidomics in the Diagnosis of Alzheimer’s Disease and Type 2 Diabetes Mellitus
by Markéta Vaňková, Marta Velíková, Daniela Vejražková, Josef Včelák, Petra Lukášová, Robert Rusina, Hana Vaňková, Eva Jarolímová, Radmila Kancheva, Josef Bulant, Lenka Horáčková, Běla Bendlová and Martin Hill
Int. J. Mol. Sci. 2023, 24(10), 8575; https://doi.org/10.3390/ijms24108575 - 10 May 2023
Cited by 1 | Viewed by 1623
Abstract
Epidemiological studies suggest an association between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM). This study aimed to investigate the pathophysiological markers of AD vs. T2DM for each sex separately and propose models that would distinguish control, AD, T2DM, and AD-T2DM comorbidity [...] Read more.
Epidemiological studies suggest an association between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM). This study aimed to investigate the pathophysiological markers of AD vs. T2DM for each sex separately and propose models that would distinguish control, AD, T2DM, and AD-T2DM comorbidity groups. AD and T2DM differed in levels of some circulating steroids (measured mostly by GC-MS) and in other observed characteristics, such as markers of obesity, glucose metabolism, and liver function tests. Regarding steroid metabolism, AD patients (both sexes) had significantly higher sex hormone binding globulin (SHBG), cortisol, and 17-hydroxy progesterone, and lower estradiol and 5α-androstane-3α,17β-diol, compared to T2DM patients. However, compared to healthy controls, changes in the steroid spectrum (especially increases in levels of steroids from the C21 group, including their 5α/β-reduced forms, androstenedione, etc.) were similar in patients with AD and patients with T2DM, though more expressed in diabetics. It can be assumed that many of these steroids are involved in counter-regulatory protective mechanisms that mitigate the development and progression of AD and T2DM. In conclusion, our results demonstrated the ability to effectively differentiate AD, T2DM, and controls in both men and women, distinguish the two pathologies from each other, and differentiate patients with AD and T2DM comorbidities. Full article
(This article belongs to the Special Issue Steroidomics in Physiology and Pathophysiology)
8 pages, 479 KiB  
Article
Vitamin D as a Possible COVID-19 Prevention Strategy
by Marie Bičíková, Ludmila Máčová and Martin Hill
Int. J. Mol. Sci. 2022, 23(18), 10532; https://doi.org/10.3390/ijms231810532 - 11 Sep 2022
Cited by 3 | Viewed by 2274
Abstract
Vitamin D is no longer considered an agent only affecting calcium phosphate metabolism. A number of studies over the past few years have demonstrated its role in immunomodulation and its influence on the development and functioning of the brain and nervous system. In [...] Read more.
Vitamin D is no longer considered an agent only affecting calcium phosphate metabolism. A number of studies over the past few years have demonstrated its role in immunomodulation and its influence on the development and functioning of the brain and nervous system. In the current epidemiological crisis caused by coronavirus disease 2019 (COVID-19), the immunoprotective role of vitamin D has been discussed by some authors regarding whether it contributes to protection against this serious disease or whether its use does not play a role. Non-standard approaches taken by laboratories in examining the serum levels of the vitamin D metabolite calcidiol have contributed to inconsistent results. We examined the serum of 60 volunteers in the spring and autumn of 2021 who declared whether they were taking vitamin D at the time of sampling. Furthermore, the tested participants noted whether they had experienced COVID-19. A newly developed liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was used to measure calcidiol levels. The analysis of variance (ANOVA) model of Statgraphics Centurion 18 statistical software from Statgraphics Technologies was used for calculations. The results of this study showed that those who took vitamin D suffered significantly less often from COVID-19 than those who did not take vitamin D. Full article
(This article belongs to the Special Issue Steroidomics in Physiology and Pathophysiology)
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Review

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36 pages, 2464 KiB  
Review
Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine
by Lucie Kolatorova, Jana Vitku, Josef Suchopar, Martin Hill and Antonin Parizek
Int. J. Mol. Sci. 2022, 23(14), 7989; https://doi.org/10.3390/ijms23147989 - 20 Jul 2022
Cited by 34 | Viewed by 12311
Abstract
Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid [...] Read more.
Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid have been documented, of which its neuro- and immunoprotective activities are the most widely discussed. Discoveries of the novel biological activities of progesterone have also driven research and development in the field of progesterone analogues used in human medicine. Progestogen treatment has traditionally and predominately been used in maintaining pregnancy, the prevention of preterm labor, various gynecological pathologies, and in lowering the negative effects of menopause. However, there are also various other medical fields where progesterone and its analogues could find application in the future. The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of progesterone and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment. Full article
(This article belongs to the Special Issue Steroidomics in Physiology and Pathophysiology)
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