Phage Display of Antibodies: Techniques and Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 May 2016) | Viewed by 122
Special Issue Editors
Interests: combinatorial peptides; cell signaling; directed evolution; mapping protein–protein interactions; phage-display; protein interaction modules; protein scaffolds; recombinant affinity reagents
Interests: antibody engineering; biotechnology; high-throughput biology; DNA sequencing technology; protein engineering; directed evolution; phage display; surface display; gene design; gene cloning and protein expression; mutagenesis; microfluidics; emulsions; barcoding and labeling
Special Issue Information
Dear Colleagues,
Phage display of antibody fragments is a powerful methodology for generating recombinant affinity reagents to many protein targets. As sequenced reagents, they offer renewability and options for engineering that are commonly lacking with polyclonal and monoclonal antibodies. It is now possible to devise and implement a pipeline for developing high quality (i.e., specific, dissociation constants of <10 nM) antibodies to almost any protein target for basic science research, diagnostic, and therapeutic applications. This Special Issue of the International Journal of Molecular Sciences will feature different aspects of a high-throughput pipeline, solutions to bottlenecks in the process, and some exciting new applications of recombinant antibodies.
Prof. Dr. Brian K. Kay
Dr. Michael P. Weiner
Guest Editors
Manuscript Submission Information
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Keywords
- affinity
- antibody fragments
- affinity maturation
- affinity selection
- IgG
- membrane proteins
- protein engineering
- recombinant affinity reagents
- specificity
