Molecular Mechanisms of Oxidative Stress Signalling Pathways in Human Diseases

Dear Colleagues,

Reactive oxygen species (ROS) have emerged as critical second messengers that modulate numerous signalling pathways under normal and pathological conditions. ROS may be continuously generated in cells in various circumstances, including inflammation, infection, chemical stress, UV rays, and radiation exposure. Controlled amounts of certain oxidants play crucial roles in cell signalling, stimulating redox-sensitive pathways and modulating cytoprotective regulatory proteins. In a healthy cell, the redox state is regulated by an endogenous antioxidant system composed of enzymatic and non-enzymatic proteins that can rapidly neutralize or minimize the production of reactive species. Excessive ROS production can disrupt the balance of pro-oxidants and antioxidant systems, leading to DNA, protein, and cell damage, promoting mutations, and triggering carcinogenesis or deregulated cell death.

The present Special Issue aims to publish the latest research advancements from the point of view of the natural compounds or nutrients and cell signalling pathways associated with oxidative stress. To identify new interventions and molecular targets that focus on the relationship between ROS and cellular responses in different pathologies of various diseases.

Prof. Dr. Shih-Min Hsia
Guest Editor

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• molecular targets of ROS in oxidative-stress-related diseases
• ROS-related signalling pathway
• cellular response to oxidative stress
• oxidative stress and related cell signalling
• biomarkers of oxidative stress in disease
• beneficial effects of natural or synthetic antioxidants in oxidative-stress-related diseases