Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Implant and Graft Interactions with Hard and Soft Tissues (Volume 2)

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 5805

Share This Special Issue

Special Issue Editors

Dr. Luigi Canullo

E-Mail Website
Guest Editor

Department of Surgical Sciences, University of Genova, 16132 Genoa, Italy
Interests: dental implants; bone regeneration; scaffolds; biomaterials; bone tissue engineering
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Eriberto Bressan

E-Mail
Guest Editor

Department of Neurosciences, Dental School, University of Padua, Padua, Italy
Interests: peri-implant disease; dental implant; fixed conometric prosthesis; biomaterials; stem cells
Special Issues, Collections and Topics in MDPI journals

Dr. Giulia Brunello

E-Mail
Guest Editor

1. Department of Oral Surgery, University of Düsseldorf, Düsseldorf, Germany
2. Department of Neurosciences, Dental School, University of Padua, Padua, Italy
Interests: dental implants; bone regeneration; scaffolds; biomaterials; bone tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue follows the publication of the first edition on “Implant and Graft Interactions with Hard and Soft Tissues”, which presented 10 interesting papers.

The interaction between implanted materials and the bone/soft tissue complex is the new frontier of implant dentistry. This observation arises from the increased number of critical patients in whom the traditional protocols and materials might result in partial success, if not failure. Traditional dental implant approaches and materials have been demonstrated to have an impressively high success rate in healthy patients. However, the aging of the global population and the consequent increase in requests for these procedures, even in older and systemically compromised patients, expose clinicians to failures.

A complete knowledge of the biomolecular exchanges and biophysics behind implant insertion and bone regeneration procedures could help industries to develop more advanced surgical tools and materials. From a practical standpoint, this might support the clinicians in improving the quality of their procedures, making every surgical and prosthetic step more predictable, even in critical cases.

The aim of this Special Issue is to investigate the biological background of implant and graft material interactions with bone through molecular science.

Dr. Luigi Canullo
Prof. Dr. Eriberto Bressan
Dr. Giulia Brunello
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

bone integration
dental implant surface
soft tissue integration
molecular biology

Published Papers (3 papers)

Download All Papers

Research

Jump to: Review

19 pages, 18127 KiB

Open AccessArticle

Synthesis and Evaluation of a Chitosan–Silica-Based Bone Substitute for Tissue Engineering

by María I. Alvarez Echazú, Sandra J. Renou, Gisela S. Alvarez, Martín F. Desimone and Daniel G. Olmedo

Int. J. Mol. Sci. 2022, 23(21), 13379; https://doi.org/10.3390/ijms232113379 - 02 Nov 2022

Cited by 6 | Viewed by 1459

Abstract

Bone defects have prompted the development of biomaterial-based bone substitutes for restoring the affected tissue completely. Although many biomaterials have been designed and evaluated, the combination of properties required in a biomaterial for bone tissue engineering still poses a challenge. In this study, a chitosan–silica-based biocomposite was synthetized, and its physicochemical characteristics and biocompatibility were characterized, with the aim of exploring the advantages and drawbacks of its use in bone tissue engineering. Dynamic light scattering measurements showed that the mean hydrodynamic size of solid silica particles (Sol-Si) was 482 ± 3 nm. Scanning electron microscopy of the biocomposite showed that Sol-Si were homogenously distributed within the chitosan (CS) matrix. The biocomposite swelled rapidly and was observed to have no cytotoxic effect on the [3T3] cell line within 24 h. Biocompatibility was also analyzed in vivo 14 days post-implant using a murine experimental model (Wistar rats). The biocomposite was implanted in the medullary compartment of both tibiae (n = 12). Histologically, no acute inflammatory infiltrate or multinucleated giant cells associated to the biocomposite were observed, indicating good biocompatibility. At the tissue–biocomposite interface, there was new formation of woven bone tissue in close contact with the biocomposite surface (osseointegration). The new bone formation may be attributed to the action of silica. Free silica particles originating from the biocomposite were observed at the tissue–biocomposite interface. According to our results, the biocomposite may act as a template for cellular interactions and extracellular matrix formation, providing a structural support for new bone tissue formation. The CS/Sol-Si biocomposite may act as a Si reservoir, promoting new bone formation. A scaffold with these properties is essential for cell differentiation and filling a bone defect. Full article

(This article belongs to the Special Issue Implant and Graft Interactions with Hard and Soft Tissues (Volume 2))

► Show Figures

Figure 1

15 pages, 3158 KiB

Open AccessArticle

Effect of Titanium and Zirconia Nanoparticles on Human Gingival Mesenchymal Stromal Cells

by Michael Nemec, Christian Behm, Vera Maierhofer, Jonas Gau, Anastasiya Kolba, Erwin Jonke, Xiaohui Rausch-Fan and Oleh Andrukhov

Int. J. Mol. Sci. 2022, 23(17), 10022; https://doi.org/10.3390/ijms231710022 - 02 Sep 2022

Cited by 4 | Viewed by 1726

Abstract

Nano- and microparticles are currently being discussed as potential risk factors for peri-implant disease. In the present study, we compared the responses of human gingival mesenchymal stromal cells (hG-MSCs) on titanium and zirconia nanoparticles (<100 nm) in the absence and presence of Porphyromonas gingivalis lipopolysaccharide (LPS). The primary hG-MSCs were treated with titanium and zirconia nanoparticles in concentrations up to 2.000 µg/mL for 24 h, 72 h, and 168 h. Additionally, the cells were treated with different nanoparticles (25–100 µg/mL) in the presence of P. gingivalis LPS for 24 h. The cell proliferation and viability assay and live–dead and focal adhesion stainings were performed, and the expression levels of interleukin (IL)-6, IL-8, and monocyte chemoattractant protein (MCP)-1 were measured. The cell proliferation and viability were inhibited by the titanium (>1000 µg/mL) but not the zirconia nanoparticles, which was accompanied by enhanced apoptosis. Both types of nanoparticles (>25 µg/mL) induced the significant expression of IL-8 in gingival MSCs, and a slightly higher effect was observed for titanium nanoparticles. Both nanoparticles substantially enhanced the P. gingivalis LPS-induced IL-8 production; a higher effect was observed for zirconia nanoparticles. The production of inflammatory mediators by hG-MSCs is affected by the nanoparticles. This effect depends on the nanoparticle material and the presence of inflammatory stimuli. Full article

(This article belongs to the Special Issue Implant and Graft Interactions with Hard and Soft Tissues (Volume 2))

► Show Figures

Figure 1

Review

Jump to: Research

17 pages, 693 KiB

Open AccessReview

Biomarkers from Peri-Implant Crevicular Fluid (PICF) as Predictors of Peri-Implant Bone Loss: A Systematic Review

by Francesca Delucchi, Camilla Canepa, Luigi Canullo, Paolo Pesce, Gaetano Isola and Maria Menini

Int. J. Mol. Sci. 2023, 24(4), 3202; https://doi.org/10.3390/ijms24043202 - 06 Feb 2023

Cited by 3 | Viewed by 2157

Abstract

The aim of the present systematic review is to summarize current knowledge regarding the analysis of biomarkers extracted from peri-implant crevicular fluid (PICF) as predictors of peri-implant bone loss (BL). An electronic search was conducted on three databases, PubMed/MEDLINE, Cochrane Library, and Google Scholar, to find clinical trials published until 1 December 2022 suitable to answer the following focused question: in patients with dental implants, are biomarkers harvested from PICF predictive of peri-implant BL? The initial search yielded a total of 158 entries. After a full-text review and application of the eligibility criteria, the final selection consisted of nine articles. The risk of bias in included studies was assessed using the Joanna Briggs Institute Critical Appraisal tools (JBI). According to the present systematic review, some inflammatory biomarkers harvested from PICF (collagenase-2, collagenase-3, ALP, EA, gelatinase b, NTx, procalcitonin, IL-1β, and several miRNAs) seem to be correlated with peri-implant BL and may assist in the early diagnosis of pathological BL, that characterizes peri-implantitis. MiRNA expression demonstrated a predictive potential of peri-implant BL that could be useful for host-targeted preventive and therapeutic purposes. PICF sampling may represent a promising, noninvasive, and repeatable form of liquid biopsy in implant dentistry. Full article

(This article belongs to the Special Issue Implant and Graft Interactions with Hard and Soft Tissues (Volume 2))

► Show Figures