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Antimicrobial and Antiviral Peptides

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 739

Special Issue Editor


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Guest Editor
Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
Interests: antimicrobial peptides; serum protein-derived peptides; infectious diseases; anti-infective peptides; anti-biofilm peptides; structure–activity relationship of peptides; in silico analysis
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Special Issue Information

Dear Colleagues,

Infectious diseases still constitute a major problem for public health in relation to the emergence of resistance against conventional antiinfective drugs. It is therefore necessary to identify new therapeutic strategies against infections. In the last twenty years, peptides have experienced a revival as potential therapeutic drugs thanks to new chemical synthesis procedures and the nano-delivery technologies applied in the peptide field.

This Special Issue aims to highlight the recent research in the field of antimicrobial and antiviral peptides. This includes, but is not limited to, (i) identification of novel natural, synthetic or in silico-designed peptides, (ii) functional and structural characterization and structure–function relationships, (iii) identification of molecular targets and (iv) possible biomedical applications.

Since International Journal of Molecular Sciences is a journal of molecular science, pure clinical studies will not be suitable for the journal. However, clinical submissions with biomolecular experiments are welcomed.

Dr. Tecla Ciociola
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial peptides
  • antiviral peptides
  • peptide mining
  • molecular mechanism of biological activity
  • structure–activity relationship
  • molecular targets
  • in silico design
  • in vivo models
  • peptide delivery strategies
  • biomedical applications

Published Papers (1 paper)

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Review

19 pages, 1652 KiB  
Review
Antimicrobial Peptides towards Clinical Application—A Long History to Be Concluded
by Laura Cresti, Giovanni Cappello and Alessandro Pini
Int. J. Mol. Sci. 2024, 25(9), 4870; https://doi.org/10.3390/ijms25094870 - 29 Apr 2024
Viewed by 224
Abstract
Antimicrobial peptides (AMPs) are molecules with an amphipathic structure that enables them to interact with bacterial membranes. This interaction can lead to membrane crossing and disruption with pore formation, culminating in cell death. They are produced naturally in various organisms, including humans, animals, [...] Read more.
Antimicrobial peptides (AMPs) are molecules with an amphipathic structure that enables them to interact with bacterial membranes. This interaction can lead to membrane crossing and disruption with pore formation, culminating in cell death. They are produced naturally in various organisms, including humans, animals, plants and microorganisms. In higher animals, they are part of the innate immune system, where they counteract infection by bacteria, fungi, viruses and parasites. AMPs can also be designed de novo by bioinformatic approaches or selected from combinatorial libraries, and then produced by chemical or recombinant procedures. Since their discovery, AMPs have aroused interest as potential antibiotics, although few have reached the market due to stability limits or toxicity. Here, we describe the development phase and a number of clinical trials of antimicrobial peptides. We also provide an update on AMPs in the pharmaceutical industry and an overall view of their therapeutic market. Modifications to peptide structures to improve stability in vivo and bioavailability are also described. Full article
(This article belongs to the Special Issue Antimicrobial and Antiviral Peptides)
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