Role of the Circadian Rhythm in Cancer Pathogenesis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 3610
Special Issue Editor
Interests: circadian rhythm; clock genes; chronotherapy; epigenetics; lung infections; immunology; cystic fibrosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The circadian clock driven by the daily light–dark and temperature cycles of the environment regulates fundamental physiological processes and perturbations of these sophisticated mechanisms may result in pathological conditions, including tumor development. A circadian regulation has been proposed for key aspects of cancer cell biology, including cell cycle, genotoxic stress response and metabolism. In particular, several intersections have been identified between clock components and proteins involved in cancerogenesis, including oncogenes and tumor suppressors. A tumor suppressor function has been hypothesized for the circadian proteins themselves, although several studies have suggested that circadian factors might have context-dependent pro-tumorigenic and anti-tumorigenic roles. In addition, the tumor itself might regulate the circadian homeostasis, thus suggesting a reciprocal regulation between tumorigenesis and circadian rhythms. Here, we propose to collect studies focusing on how the circadian clock interfaces with many oncogenes and tumor suppressors. We particularly welcome manuscripts on the following subjects:
- Regulation of oncogenes and tumor suppressors by the circadian clock;
- Tissue-specific circadian control of tumorigenesis;
- Role of clock genes as putative oncogenes/tumor suppressor genes;
- Deregulation of circadian rhythms by oncogenes or tumor suppressors.
Dr. Marina Maria Bellet
Guest Editor
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Keywords
- circadian rhythm
- clock genes
- oncogenes
- tumor suppressors
- tumorigenesis
