Dear Colleagues,

Drug resistance is the main obstacle to the successful treatment of cancer patients. Therefore, new approaches to study drug resistance in cancer as well as novel drugs and strategies to overcome drug resistance are required.

Particular attention will be given to research methods, such as computational approaches to predict drug response and drug interaction and laboratory-based research approaches. Such approaches will allow the identification of novel mechanistic insights that will lead to the discovery of novel biomarkers for drug response. Additional novel insights in epigenetic, mutational, or transcriptomic landscapes leading to the identification of novel therapeutic targets or biomarkers for patient classification or to monitor the response to therapy are also of interest for publication in this Special Issue.

Submissions on the following topics are invited:

• computational modeling approaches to studying drug resistance
• integrative bioinformatics analysis for omics studies with implications in biomarker discovery; data integration for early detection of tumors allowing the interception of cancer and adaptive monitoring during therapy
• biological determinants of resistance, particular those related to the tumor microenvironment
• novel drugs and improved pharmacological principles capable of counteracting drug resistance mechanisms

The Special Issue will include original and review papers presenting outstanding data on all aspects of drug resistance mechanisms in cancer.

Assoc. Pro Cornelia Braicu
Dr. Ioana Berindan-Neagoe
Dr. Ancuta Jurj
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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• cancer drug resistance
• drug resistance mechanisms
• resistance modulation
• combined therapy
• biomarkers for monitoring drug response