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Advances in Materials and Biomaterials in Dental Implantology
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Advances in Materials and Biomaterials in Dental Implantology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 7608

Special Issue Editors

Prof. Dr. Ralf Smeets

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Interests: biomaterials; tissue engineering; resorbable metals; drug delivery systems; surface modifications
Special Issues, Collections and Topics in MDPI journals
Dr. Anders Henningsen

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Interests: osseointegration; dental implants; biomaterials; non-thermal plasma; UV-light; platform switch implants; bone augmentation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The reconstruction and regeneration of the alveolar bone and the surrounding soft tissues is of great and ongoing clinical interest and relevance. Recently, many biomaterials have been introduced for reconstructive or regenerative purposes.

The current goal of research on biomaterials in dental implantology is to promote and support the regeneration of the target tissue. Through continued research, materials have become more biocompatible, more absorbable, and less susceptible to foreign body reactions. However, in vitro, in vivo and clinical studies are imperative to evaluate cellular and molecular interactions with biomaterials and their behavior in living organisms, as well as to confirm the complete biodegradation of the biomaterials used.

In this Special Issue, we would like to highlight the current developments and trends in the optimization of biomaterials for reconstructive and regenerative purposes in dental implantology.

We therefore welcome contributions in the form of reviews and/or original papers that discuss innovative ideas regarding new biomaterials, as well as their optimization, surface modifications, innovative manufacturing, or application methods, and the behavior of these materials in vitro, in vivo or in the clinic.

Prof. Dr. Ralf Smeets
Dr. Anders Henningsen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • dentistry
  • biocompatible materials
  • tissue regeneration
  • reconstructive surgical procedures
  • tissue engineering
  • biomedical engineering
  • bioengineering
  • dental implants

Related Special Issues

Published Papers (4 papers)

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Research

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12 pages, 2641 KiB  
Article
In Vitro Study of Zirconia Surface Modification for Dental Implants by Atomic Layer Deposition
by Tatsuhide Hayashi, Masaki Asakura, Shin Koie, Shogo Hasegawa, Akimichi Mieki, Koki Aimu and Tatsushi Kawai
Int. J. Mol. Sci. 2023, 24(12), 10101; https://doi.org/10.3390/ijms241210101 - 14 Jun 2023
Viewed by 1327
Abstract
Zirconia is a promising material for dental implants; however, an appropriate surface modification procedure has not yet been identified. Atomic layer deposition (ALD) is a nanotechnology that deposits thin films of metal oxides or metals on materials. The aim of this study was [...] Read more.
Zirconia is a promising material for dental implants; however, an appropriate surface modification procedure has not yet been identified. Atomic layer deposition (ALD) is a nanotechnology that deposits thin films of metal oxides or metals on materials. The aim of this study was to deposit thin films of titanium dioxide (TiO2), aluminum oxide (Al2O3), silicon dioxide (SiO2), and zinc oxide (ZnO) on zirconia disks (ZR-Ti, ZR-Al, ZR-Si, and ZR-Zn, respectively) using ALD and evaluate the cell proliferation abilities of mouse fibroblasts (L929) and mouse osteoblastic cells (MC3T3-E1) on each sample. Zirconia disks (ZR; diameter 10 mm) were fabricated using a computer-aided design/computer-aided manufacturing system. Following the ALD of TiO2, Al2O3, SiO2, or ZnO thin film, the thin-film thickness, elemental distribution, contact angle, adhesion strength, and elemental elution were determined. The L929 and MC3T3-E1 cell proliferation and morphologies on each sample were observed on days 1, 3, and 5 (L929) and days 1, 4, and 7 (MC3T3-E1). The ZR-Ti, ZR-Al, ZR-Si, and ZR-Zn thin-film thicknesses were 41.97, 42.36, 62.50, and 61.11 nm, respectively, and their average adhesion strengths were 163.5, 140.9, 157.3, and 161.6 mN, respectively. The contact angle on ZR-Si was significantly lower than that on all the other specimens. The eluted Zr, Ti, and Al amounts were below the detection limits, whereas the total Si and Zn elution amounts over two weeks were 0.019 and 0.695 ppm, respectively. For both L929 and MC3T3-E1, the cell numbers increased over time on ZR, ZR-Ti, ZR-Al, and ZR-Si. Particularly, cell proliferation in ZR-Ti exceeded that in the other samples. These results suggest that ALD application to zirconia, particularly for TiO2 deposition, could be a new surface modification procedure for zirconia dental implants. Full article
(This article belongs to the Special Issue Advances in Materials and Biomaterials in Dental Implantology)
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13 pages, 5900 KiB  
Article
Study on New Dental Materials Containing Quinoxaline-Based Photoinitiators in Terms of Exothermicity of the Photopolymerization Process
by Ilona Pyszka, Łukasz Skowroński and Beata Jędrzejewska
Int. J. Mol. Sci. 2023, 24(3), 2752; https://doi.org/10.3390/ijms24032752 - 1 Feb 2023
Cited by 10 | Viewed by 1275
Abstract
Modern dentistry places great demands on the dental composites used for filling tooth cavities or treating cavitated tooth decay. The aim of the work was to modify the properties of composites by changing the initiators and co-initiators. This was achieved by using initiators [...] Read more.
Modern dentistry places great demands on the dental composites used for filling tooth cavities or treating cavitated tooth decay. The aim of the work was to modify the properties of composites by changing the initiators and co-initiators. This was achieved by using initiators based on a quinoxaline skeleton and co-initiators that are derivatives of acetic acid, which is an advantage of these photoinitiating systems due to the elimination of aromatic amines from the photocurable composition. The composites also differed in dental fillers. The effect of the compounds on the exothermicity of the photopolymerization process, the surface morphology of the obtained materials and the maximum compressive strength were determined. The photoinitiating capacity of the two-component systems was tested by the microcalorimetric method using the multifunctional monomer TMPTA, typical for dental filler compositions. The new photoinitiating systems show particularly good efficiency of free radical polymerization initiation, which occurs by the photoinduced intermolecular electron transfer (PET) mechanism. The comparison of the tested systems with camphorquinone, a photoinitiator traditionally used in dentistry, made it possible to observe a decrease in temperature during photopolymerization without a significant decrease in the polymerization rate or increase in photocuring time, as well as a better homogeneity of the surface of the obtained polymeric materials. This indicates that dye–acetic acid derivative systems may be useful in dental applications. Full article
(This article belongs to the Special Issue Advances in Materials and Biomaterials in Dental Implantology)
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28 pages, 5749 KiB  
Article
In-Vitro Biofilm Removal Efficacy Using Water Jet in Combination with Cold Plasma Technology on Dental Titanium Implants
by Rutger Matthes, Lukasz Jablonowski, Lea Miebach, Vinay Pitchika, Birte Holtfreter, Christian Eberhard, Leo Seifert, Torsten Gerling, Rabea Schlüter, Thomas Kocher and Sander Bekeschus
Int. J. Mol. Sci. 2023, 24(2), 1606; https://doi.org/10.3390/ijms24021606 - 13 Jan 2023
Cited by 3 | Viewed by 2034
Abstract
Peri-implantitis-associated inflammation can lead to bone loss and implant failure. Current decontamination measures are ineffective due to the implants’ complex geometry and rough surfaces providing niches for microbial biofilms. A modified water jet system (WaterJet) was combined with cold plasma technology (CAP) to [...] Read more.
Peri-implantitis-associated inflammation can lead to bone loss and implant failure. Current decontamination measures are ineffective due to the implants’ complex geometry and rough surfaces providing niches for microbial biofilms. A modified water jet system (WaterJet) was combined with cold plasma technology (CAP) to achieve superior antimicrobial efficacy compared to cotton gauze treatment. Seven-day-old multi-species-contaminated titanium discs and implants were investigated as model systems. The efficacy of decontamination on implants was determined by rolling the implants over agar and determining colony-forming units supported by scanning electron microscopy image quantification of implant surface features. The inflammatory consequences of mono and combination treatments were investigated with peripheral blood mononuclear cell surface marker expression and chemokine and cytokine release profiles on titanium discs. In addition, titanium discs were assayed using fluorescence microscopy. Cotton gauze was inferior to WaterJet treatment according to all types of analysis. In combination with the antimicrobial effect of CAP, decontamination was improved accordingly. Mono and CAP-combined treatment on titanium surfaces alone did not unleash inflammation. Simultaneously, chemokine and cytokine release was dramatically reduced in samples that had benefited from additional antimicrobial effects through CAP. The combined treatment with WaterJet and CAP potently removed biofilm and disinfected rough titanium implant surfaces. At the same time, non-favorable rendering of the surface structure or its pro-inflammatory potential through CAP was not observed. Full article
(This article belongs to the Special Issue Advances in Materials and Biomaterials in Dental Implantology)
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Review

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20 pages, 1028 KiB  
Review
Tissue Adhesives in Reconstructive and Aesthetic Surgery—Application of Silk Fibroin-Based Biomaterials
by Ralf Smeets, Nathalie Tauer, Tobias Vollkommer, Martin Gosau, Anders Henningsen, Philip Hartjen, Leonie Früh, Thomas Beikler, Ewa K. Stürmer, Rico Rutkowski, Audrey Laure Céline Grust, Sandra Fuest, Robert Gaudin and Farzaneh Aavani
Int. J. Mol. Sci. 2022, 23(14), 7687; https://doi.org/10.3390/ijms23147687 - 12 Jul 2022
Cited by 5 | Viewed by 2340
Abstract
Tissue adhesives have been successfully used in various kind of surgeries such as oral and maxillofacial surgery for some time. They serve as a substitute for suturing of tissues and shorten treatment time. Besides synthetic-based adhesives, a number of biological-based formulations are finding [...] Read more.
Tissue adhesives have been successfully used in various kind of surgeries such as oral and maxillofacial surgery for some time. They serve as a substitute for suturing of tissues and shorten treatment time. Besides synthetic-based adhesives, a number of biological-based formulations are finding their way into research and clinical application. In natural adhesives, proteins play a crucial role, mediating adhesion and cohesion at the same time. Silk fibroin, as a natural biomaterial, represents an interesting alternative to conventional medical adhesives. Here, the most commonly used bioadhesives as well as the potential of silk fibroin as natural adhesives will be discussed. Full article
(This article belongs to the Special Issue Advances in Materials and Biomaterials in Dental Implantology)
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