Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers

Dear Colleagues,

Chronic kidney disease (CKD) is a worldwide public health problem, the prevalence of which has been increasing significantly in recent years, creating a significant economic burden. In its early stages, CKD is usually asymptomatic and is often undiagnosed, given the low sensitivity of classic kidney biomarkers to identifying early renal damage. Knowledge of kidney disease biology, and namely of the biomolecules and molecular mechanisms that play key roles in its development and progression, is crucial for improving the management of this condition. The elucidation of the molecular signaling pathways involved in critical components of CKD-related pathologies, such as inflammation, oxidative stress, anemia, and renal fibrosis, is the first step in achieving early diagnoses and effective monitoring. Further, any attempt to identify the biomolecules that can be used as biomarkers of early renal lesions and of kidney disease progression should be encouraged. Reliable biomarkers will assist clinicians in diagnosis and treatment monitoring, avoiding, or minimizing, the worsening of CKD.

In this Special Issue, we intend to gather manuscripts that debate/report on recent advances in knowledge of kidney disease, from its biology to its biomarkers of interest.

Dr. Susana Coimbra
Dr. Flávio Reis
Dr. Alice Santos-Silva
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• chronic kidney disease (CKD)
• end-stage renal disease
• CKD biomarkers
• CKD progression
• metabolomics
• molecular pathways
• biomolecules
• CKD anemia
• cardiovascular disease risk
• CKD-related disease