Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Natural Products as Multitarget Agents in Human Diseases
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Natural Products as Multitarget Agents in Human Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1002

Special Issue Editors

Dr. Andrey Marchev

E-Mail Website
Guest Editor
Laboratory of Metabolomics, Department of Biotechnology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd, 4000 Plovdiv, Bulgaria
Interests: natural products; plant-derived extracts and molecules; medicinal plants; plant in vitro systems; natural products pharmacology
Special Issues, Collections and Topics in MDPI journals
Dr. Nikolina Mihaylova

E-Mail Website
Guest Editor
Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: autoimmunity; osteoarthritis; B cells; T cells; cell signaling; mouse models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to share your scientific achievements in the field of natural products (extracts and/or pure molecules derived from natural sources) that are utilized as potential novel therapeutic agents targeting wide spectrum of human diseases.

For centuries, natural products (NPs) have been proven as agents with numerous health benefits for humans and explored as a pool for the development of novel therapeutic drugs. Because of the side effects associated with conventional therapies, the search for novelty and safety from NPs with proven therapeutic qualities is increasingly imperative. It is absolutely necessary to validate the bioactivity of the NPs studied, to prove their quality, effectiveness, and safety, while simultaneously clarify their possible molecular mechanism, including interactions with conventional drugs.

The aim of this Special Issue (SI) is to present high-quality novel research findings that evaluate the therapeutic effects of NPs with focus on the physiological, biochemical, and molecular processes underlying their mechanism of activity in in vitro and in vivo studies related to human health. The SI will accept original research articles, short communications, and reviews.

Dr. Andrey Marchev
Dr. Nikolina Mihaylova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • bioactive compounds
  • human health
  • disease prevention and treatment
  • molecular and physiological mechanism
  • inflammatory diseases
  • cancer
  • arthritic diseases
 

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

18 pages, 8366 KiB  
Article
Isorhamnetin Alleviates Mitochondrial Injury in Severe Acute Pancreatitis via Modulation of KDM5B/HtrA2 Signaling Pathway
by Xiaojuan Li, Tao Wang, Qilong Zhou, Fan Li, Ting Liu, Kun Zhang, Ao Wen, Lijuan Feng, Xiaoling Shu, Simin Tian, Yijiang Liu, Yu Gao, Qing Xia, Guang Xin and Wen Huang
Int. J. Mol. Sci. 2024, 25(7), 3784; https://doi.org/10.3390/ijms25073784 - 28 Mar 2024
Viewed by 486
Abstract
Severe acute pancreatitis (SAP), a widespread inflammatory condition impacting the abdomen with a high mortality rate, poses challenges due to its unclear pathogenesis and the absence of effective treatment options. Isorhamnetin (ISO), a naturally occurring flavonoid, demonstrates robust antioxidant and anti-inflammatory properties intricately [...] Read more.
Severe acute pancreatitis (SAP), a widespread inflammatory condition impacting the abdomen with a high mortality rate, poses challenges due to its unclear pathogenesis and the absence of effective treatment options. Isorhamnetin (ISO), a naturally occurring flavonoid, demonstrates robust antioxidant and anti-inflammatory properties intricately linked to the modulation of mitochondrial function. However, the specific protective impact of ISO on SAP remains to be fully elucidated. In this study, we demonstrated that ISO treatment significantly alleviated pancreatic damage and reduced serum lipase and amylase levels in the mouse model of SAP induced by sodium taurocholate (STC) or L-arginine. Utilizing an in vitro SAP cell model, we found that ISO co-administration markedly prevented STC-induced pancreatic acinar cell necrosis, primarily by inhibiting mitochondrial ROS generation, preserving ATP production, maintaining mitochondrial membrane potential, and preventing the oxidative damage and release of mitochondrial DNA. Mechanistically, our investigation identified that high-temperature requirement A2 (HtrA2) may play a central regulatory role in mediating the protective effect of ISO on mitochondrial dysfunction in STC-injured acinar cells. Furthermore, through an integrated approach involving bioinformatics analysis, molecular docking analysis, and experimental validation, we uncovered that ISO may directly impede the histone demethylation activity of KDM5B, leading to the restoration of pancreatic HtrA2 expression and thereby preserving mitochondrial function in pancreatic acinar cells following STC treatment. In conclusion, this study not only sheds new light on the intricate molecular complexities associated with mitochondrial dysfunction during the progression of SAP but also underscores the promising value of ISO as a natural therapeutic option for SAP. Full article
(This article belongs to the Special Issue Natural Products as Multitarget Agents in Human Diseases)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop