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Carbon-Based Materials for Therapeutic Application
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Carbon-Based Materials for Therapeutic Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 3283

Special Issue Editor

Dr. Theodoros Chatzimitakos

E-Mail Website
Guest Editor
Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
Interests: nanomaterials; carbon-based nanomaterials; graphene; carbon nanodots; photoluminescent probes; sample preparation; analytical method development; metabolomics; toxicity; antibacterial activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbon-based materials exhibit numerous merits and unique properties, among other classes of nanomaterials, that derive mainly from their composition, size and surface. Their numerous properties were used to develop various applications. Among others, the stability and biocompatibility of carbon-based nanomaterials paved the way for their use in biomedical applications and pharmaceutical sciences. Since then, more and more articles have been published which suggest the use of carbon-based nanomaterials for promoting human health via diagnostic and therapeutic applications. Drug delivery, biosensing, carbon monoxide release, antibacterial, anti-inflammatory, tissue engineering, implants etc. are some of the many applications that reap the benefits of carbon nanomaterials. Research is currently focused either on developing more advanced carbon-based nanomaterials (aside from the carbon nanotubes, graphene, and fullerenes that have been studied up to now) and the functionalization of nanomaterials with therapeutic agents (e.g., oligonucleotides, aptamers), or in the development of alternative, more advanced applications. However, since human bodies are complex, it is advised to gain deeper knowledge of the mechanisms by which the therapeutic effect is achieved. In this context, omics  and molecular techniques can result in a better understanding of the topic.

This Special Issue is focused on the collection of high-quality research articles, comprehensive reviews, and novel communications in order to present the state-of-the-art research on the therapeutic applications developed using carbon-based nanomaterials. Emphasis will be placed on all therapeutic applications, including theranostics, and on the examination of molecular alterations in organisms.

This Special Issue is supervised by Dr. Chatzimitakos Theodoros and assisted by our Topical Advisory Panel Member Dr. Kasouni Athanasia (University of Ioannina).

Dr. Theodoros Chatzimitakos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon nanotubes 
  • graphene 
  • graphene oxide 
  • fullerenes 
  • carbon nanodots 
  • theranostics 
  • drug delivery 
  • cytotoxicity 
  • anti-inflammatory 
  • antibacterial 
  • photodynamic therapy 
  • molecular mechanisms 
  • metabolomics

Published Papers (2 papers)

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Research

13 pages, 8187 KiB  
Article
Graphene Oxide Nanosurface Reduces Apoptotic Death of HCT116 Colon Carcinoma Cells Induced by Zirconium Trisulfide Nanoribbons
by Victor V. Tatarskiy, Olga V. Zakharova, Peter A. Baranchikov, Dmitry S. Muratov, Denis V. Kuznetsov and Alexander A. Gusev
Int. J. Mol. Sci. 2023, 24(3), 2783; https://doi.org/10.3390/ijms24032783 - 1 Feb 2023
Cited by 2 | Viewed by 1385
Abstract
Due to their chemical, mechanical, and optical properties, 2D ultrathin nanomaterials have significant potential in biomedicine. However, the cytotoxicity of such materials, including their mutual increase or decrease, is still not well understood. We studied the effects that graphene oxide (GO) nanolayers (with [...] Read more.
Due to their chemical, mechanical, and optical properties, 2D ultrathin nanomaterials have significant potential in biomedicine. However, the cytotoxicity of such materials, including their mutual increase or decrease, is still not well understood. We studied the effects that graphene oxide (GO) nanolayers (with dimensions 0.1–3 μm and average individual flake thickness less than 1 nm) and ZrS3 nanoribbons (length more than 10 μm, width 0.4–3 μm, and thickness 50–120 nm) have on the viability, cell cycle, and cell death of HCT116 colon carcinoma cells. We found that ZrS3 exhibited strong cytotoxicity by causing apoptotic cell death, which was in contrast to GO. When adding GO to ZrS3, ZrS3 was significantly less toxic, which may be because GO inhibits the effects of cytotoxic hydrogen sulfide produced by ZrS3. Thus, using zirconium trisulfide nanoribbons as an example, we have demonstrated the ability of graphene oxide to reduce the cytotoxicity of another nanomaterial, which may be of practical importance in biomedicine, including the development of biocompatible nanocoatings for scaffolds, theranostic nanostructures, and others. Full article
(This article belongs to the Special Issue Carbon-Based Materials for Therapeutic Application)
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16 pages, 5146 KiB  
Article
From Cyclo[18]carbon to the Novel Nanostructures—Theoretical Predictions
by Agnieszka Brzyska, Tomasz Panczyk and Krzysztof Wolinski
Int. J. Mol. Sci. 2022, 23(21), 12960; https://doi.org/10.3390/ijms232112960 - 26 Oct 2022
Cited by 2 | Viewed by 1321
Abstract
In this paper, we present a number of novel pure-carbon structures generated from cyclo[18]carbon. Due to the very high reactivity of cyclo[18]carbon, it is possible to link these molecules together to form bigger molecular systems. In our studies, we generated new structures containing [...] Read more.
In this paper, we present a number of novel pure-carbon structures generated from cyclo[18]carbon. Due to the very high reactivity of cyclo[18]carbon, it is possible to link these molecules together to form bigger molecular systems. In our studies, we generated new structures containing 18, 36 and 72 carbon atoms. They are of different shapes including ribbons, sheets and tubes. All these new structures were obtained in virtual reactions driven by external forces. For every reaction, the energy requirement was evaluated exactly when the corresponding transition state was found or it was estimated through our new approach. A small HOMO–LUMO gap in these nanostructures indicates easy excitations and the multiple bonds network indicates their high reactivity. Both of these factors suggest that some potential applications of the new nanostructures are as components of therapeutically active carbon quantum dots, terminal fragments of graphene or carbon nanotubes obtained after fracture or growing in situ in catalytic reactions leading to the formation of carbonaceous materials. Full article
(This article belongs to the Special Issue Carbon-Based Materials for Therapeutic Application)
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