Natural Products and Synthetic Compounds for Drug Development 2.0

Dear Colleagues,

Nature is a rich source of bioactive compounds that have been explored as alternative therapies over the years, exhibiting interesting pharmacological properties and paving the way for the isolation and characterization of biologically active substances, as well as the development of molecular hybrids or small molecules for treating various diseases.

Nature plays a crucial role as a source of drug structures for the development of novel, effective, and safe drugs. Medicinal chemistry develops active compounds through structural simplification, hybridization, or mimicking derivatives to interact with different targets and treat a variety of human diseases. This field of research has demonstrated tremendous practicality, increasing target affinity, and addressing a range of issues affecting candidate drugs.

The theme of this Special Issue is "Natural Products and Synthetic Compounds for Drug Development", and we welcome original articles and broad reviews covering natural products, their derivatives, and synthetic compounds. Topics of interest include oxidative stress-related conditions, reactive oxygen species, oxidative damage, and inflammatory stimulation. Furthermore, we will consider applications to different human diseases, including cancer, infectious diseases, cardiovascular, and neurological diseases. We aim to provide the latest findings on the pharmacological and clinical characteristics of specific molecular compounds, the pharmacology of natural compounds, and the roles of bioactive natural products in human health and disease.

This Special Issue is supervised by Prof. Dr. Guan-Jhong Huang and assisted by our Guest Editor’s Assistant Editor Dr. Xingkang Wu (Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University).

Prof. Dr. Guan-Jhong Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• reactive oxygen
• anti-inflammation
• cancer
• infectious diseases
• liver diseases
• lung disease
• kidney disease
• cardiac disease
• neuro disease

• Natural Products and Synthetic Compounds for Drug Development in International Journal of Molecular Sciences (26 articles)