International Journal of Molecular Sciences

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Special Issue Editors

Special Issue Information

Dear Colleagues,

The concept of biomaterials emerged due to the necessity of replacing living systems. For a long time, the medical applications of biomaterials were considered based on their interactions with biological systems. Therefore, the interface and specific interactions played a vital role in the establishment of corresponding artificial systems, governing the success or failure of biological assessment. Biomaterials were a pathway to design the desired artificial systems, and for this purpose, biomaterials served as an integrated component of artificial systems, with permanent advances in nanotechnology sustaining the design of various biomaterial nanostructures with key significance of cell–biomaterial interactions at a nano-level. Today, nanotechnology has allowed biomaterials to succeed in a wide range of medical or pharmaceutical applications (tissue engineering, drug delivery, microfluidics), while the next generation of biomaterials are under development using innovative strategies. The unique developed materials aim to mimic the key features of natural biological materials, to reveal the limitation of current methodologies and materials and provide new insights for the evolution of biomaterials.

In this context, this Special Issue on “Nanotechnology: A Powerful Tool in the Scope of Tissue Engineering Domain” aims to underline novel modalities, strategies, technologies, pathways, applications, or biomaterials that are under research. Complex reviews that value the current advances and future perspectives within the biomaterials domain are encouraged.

Dr. Ionuţ Cristian Radu
Dr. Adriana Lungu
Guest Editors

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Keywords

nanotechnology
3D printing/3D bioprinting
Drug delivery
hydrogels
nanoparticles
organ-on-a-chip
nanotechnology
tissue engineering
hydrogels
nanoparticles
nanocomposites

Published Papers (1 paper)

Research

22 pages, 3077 KiB

Open AccessArticle

Influence of HA on Release Process of Anionic and Cationic API Incorporated into Hydrophilic Gel

by Dorota Wójcik-Pastuszka, Karolina Stawicka, Andrzej Dryś and Witold Musiał

Int. J. Mol. Sci. 2023, 24(6), 5606; https://doi.org/10.3390/ijms24065606 - 15 Mar 2023

Cited by 2 | Viewed by 1542

Abstract

The properties of sodium hyaluronate (HA), such as hygroscopicity, flexibility, the ability to form hydrogels, as well as biocompatibility and biodegradability, are beneficial for the applications in pharmaceutical technology, cosmetics industry, and aesthetic medicine. The aim of this study was to prepare HA-based hydrogels doped with active pharmaceutical ingredient (API): a cationic drug—lidocaine hydrochloride or anionic drug—sodium. The interaction between the carrier and the implemented active pharmaceutical substances was evaluated in prepared systems by applying viscometric measurements, performing release tests of the drug from the obtained formulations, and carrying out FTIR and DSC. The data from release studies were analyzed using the zero-, first-, and second-order kinetics and Higuchi, Korsmeyer-Peppas, and Hixon-Crowell models. The respective kinetic parameters: the release rate constants, the half-release time and, in the case of the Korsmeyer-Peppas equation, the n parameter were calculated. The variability between the obtained release profiles was studied by calculating the difference (f₁) and the similarity factor (f₂) as well as employing statistical methods. It was revealed that the incorporation of the drugs resulted in an increase in the viscosity of the hydrogels in comparison to the respective drug-free preparations. The dissolution study showed that not entire amount of the added drug was released from the formulation, suggesting an interaction between the carrier and the drug. The FTIR and DSC studies confirmed the bond formation between HA and both medicinal substances. Full article

(This article belongs to the Special Issue Nanotechnology: A Powerful Tool in the Scope of Tissue Engineering Domain)

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