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Redox Regulation and Drug Discovery

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 470

Special Issue Editor


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Guest Editor
School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
Interests: redox regulation; redox medicine; redox biology; anticancer drugs; antioxidants; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Redox regulation plays a significant role in drug target identification, drug discovery, and medical translation. It involves the regulation of the cellular redox state, which is critical for maintaining the balance between oxidative stress and antioxidant defense mechanisms. Redox regulation has been shown to affect various cellular processes, including signal transduction, gene expression, and protein function. By understanding the role of redox regulation in disease, researchers can identify new drug targets and develop more effective treatments. Redox regulation is thus an essential aspect of drug discovery and medical translation. This Special Issue will present research findings on the contribution of redox regulation in drug discovery and medical translation for the promotion of redox-balanced medicine.

You may choose our Joint Special Issue in Antioxidants.

Prof. Dr. Junmin Zhang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • redox regulation
  • drug discovery
  • medical translation
  • redox biology and medicine
  • redox homeostasis
  • redox balance
  • natural products
  • redox signaling pathways

Published Papers (1 paper)

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Research

20 pages, 4662 KiB  
Article
Effect of Poria cocos Terpenes: Verifying Modes of Action Using Molecular Docking, Drug-Induced Transcriptomes, and Diffusion Network Analyses
by Musun Park, Jin-Mu Yi, No Soo Kim, Seo-Young Lee and Haeseung Lee
Int. J. Mol. Sci. 2024, 25(9), 4636; https://doi.org/10.3390/ijms25094636 - 24 Apr 2024
Viewed by 249
Abstract
We characterized the therapeutic biological modes of action of several terpenes in Poria cocos F.A Wolf (PC) and proposed a broad therapeutic mode of action for PC. Molecular docking and drug-induced transcriptome analysis were performed to confirm the pharmacological mechanism of PC terpene, [...] Read more.
We characterized the therapeutic biological modes of action of several terpenes in Poria cocos F.A Wolf (PC) and proposed a broad therapeutic mode of action for PC. Molecular docking and drug-induced transcriptome analysis were performed to confirm the pharmacological mechanism of PC terpene, and a new analysis method, namely diffusion network analysis, was proposed to verify the mechanism of action against Alzheimer’s disease. We confirmed that the compound that exists only in PC has a unique mechanism through statistical-based docking analysis. Also, docking and transcriptomic analysis results could reflect results in clinical practice when used complementarily. The detailed pharmacological mechanism of PC was confirmed by constructing and analyzing the Alzheimer’s disease diffusion network, and the antioxidant activity based on microglial cells was verified. In this study, we used two bioinformatics approaches to reveal PC’s broad mode of action while also using diffusion networks to identify its detailed pharmacological mechanisms of action. The results of this study provide evidence that future pharmacological mechanism analysis should simultaneously consider complementary docking and transcriptomics and suggest diffusion network analysis, a new method to derive pharmacological mechanisms based on natural complex compounds. Full article
(This article belongs to the Special Issue Redox Regulation and Drug Discovery)
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