Synthetic Biology Research Based on a Yarrowia lipolytica Model
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1349
Special Issue Editor
Interests: lipid accumulation; microbial genetics; metabolic engineering; biotechnology of yeasts; algal engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Yarrowia lipolytica has gained significant interest in synthetic biology research due to its unique characteristics and metabolic capabilities. Y. lipolytica has been extensively used as a model organism in synthetic biology due to its ability to utilize a wide range of carbon sources, including various hydrophobic substrates. Researchers have used metabolic engineering techniques to enhance its lipid-accumulation capabilities to produce biofuels, oleochemicals, and other high-value lipids. Synthetic biology approaches have been employed to enhance lipid production in Y. lipolytica via engineering metabolic pathways involved in lipid synthesis and regulation. Researchers have engineered Y. lipolytica strains to produce various proteins, including therapeutic enzymes, organic acids, polymers, and pharmaceutical precursors. Its secretion machinery and post-translational modification capabilities make it suitable to produce complex proteins. Synthetic biology techniques have enabled the engineering of Y. lipolytica strains to produce enzymes with desired properties, such as thermostability, pH tolerance, or substrate specificity. Researchers have engineered Y. lipolytica strains that can be controlled or triggered by light, enabling the precise modulation of gene expression and metabolic activities. These applications make Y. lipolytica a promising platform that serves as a valuable model organism in synthetic biology for developing sustainable biotechnological solutions.
This Special Issue calls for articles and reviews related to synthetic biology research on Yarrowia lipolytica.
Dr. Jean-Marc Nicaud
Guest Editor
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Keywords
- Y. lipolytica
- synthetic biology
- metabolic engineering
- lipid accumulation
- oleochemistry
- biofuels
- sustainable biotechnology
