Role of Mutations and Polymorphisms in Various Diseases

Dear Colleagues,

Genetic polymorphisms and mutations can affect gene expression, modify the quantity and quality of the encoded product (protein), and significantly alter the metabolic pathway and its control, thus causing changes in the functioning of metabolic pathways. In this way, some changes in the genome are involved in not only the initiation but also the progression/regression of diseases.

In this Special Issue of International Journal of Molecular Sciences, we focus our attention on the latest discoveries and developments in correlations between genetic mutations, their relation with diseases in animals and human studies, and their possible underlying mechanisms. We also will study metabolic pathways that are considered to have an impact on the development of diseases, as well as genes and polymorphisms involved in the process.

We will provide a comprehensive update on the literature that is accessible to scientists from the field. Thus, we wish to invite investigators from basic, genetic, pathophysiological, nutritional, and metabolism research backgrounds or closely related disciplines to contribute original articles, reviews, communications, and conceptual papers.

Dr. Anna Cieślińska
Dr. Ewa Fiedorowicz
Guest Editors

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• nutrigenomics
• polymorphism
• SNPs
• mutations
• predisposition
• correlation
• diversity
• deletion
• insertion