Microbiota and Sepsis: Interactions and Future Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 1974
Special Issue Editor
Interests: septic shock; multidrug-resistant pathogens; severe infections; hospital infections; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dysbiosis in septic patients may play a role in determining the course of the disease by increasing systemic pro-inflammatory cytokine production. The microbiota could have therapeutic properties, although the underlying mechanism for the observed dysbiosis is unclear. Mounting evidence suggests that severe infection may have an impact on the host microbiota and gut inflammation, infecting intestinal epithelial cells and involving the microvascular system of the gastrointestinal tract. This possible link and its implications can be investigated by observing the effects of the modulation of the microbial flora in critically ill patients with severe infections.
Moreover, new data from the pandemic have highlighted the role of the lung microbiota and the dysregulation of the gut–brain–lung axis. Therefore, knowledge of the molecular mechanisms associated with microbiota modifications in septic patients and new therapeutic approaches is necessary for the early and appropriate management of severe infections. Data about the types of interventions that are the most effective according to the personal characteristics of individual patients are required.
This Special Issue aims to expand the current knowledge of the interactions between microbiota and sepsis in different stages and possible therapeutic exploitations, including new therapies. Experimental studies using in vitro and in vivo models, review articles, and clinical studies are all welcome to be submitted.
Dr. Alessandro Russo
Guest Editor
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Keywords
- sepsis
- septic shock
- microbiome
- microbionutritional status
- MDR pathogens
- therapeutic approaches
