Special Issue "Long Noncoding RNAs"

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A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Population and Evolutionary Genetics and Genomics".

Deadline for manuscript submissions: closed (31 May 2015)

Special Issue Editor

Guest Editor
Prof. Dr. Bernhard Herrmann

Director, Max-Planck-Institute for Molecular Genetics (MPI-MG), Department Developmental Genetics, Ihnestr. 63-73, D-14195 Berlin, Germany
Website | E-Mail
Interests: developmental genetics of the mouse; trunk development; regulatory networks controlling tissue formation and organ development; EMT; epigenetic control mechanisms; long noncoding RNA; tumorigenesis; non-Mendelian inheritance in the mouse

Special Issue Information

Dear Colleagues,

Improved sequencing technology has revealed a large number of genes expressing non protein-coding RNA with unknown function. One subclass, the long noncoding RNAs have recently come into focus since many have been found to be associated with histone modifying complexes involved in gene regulation and cell lineage control. So far only a small number of lncRNAs have been shown to play an important role in cell differentiation, organogenesis or cancer. However, current data suggest that lncRNAs play pivotal roles in many cellular processes besides gene regulation and nuclear organization, and may be involved in many diseases.

This special issue of Genes welcomes reviews and original papers covering recent research on the function of long noncoding RNA in embryogenesis, cell differentiation, homeostasis and disease processes. Contributions on all aspects of long noncoding RNA function are welcome.

Prof. Dr. Bernhard Herrmann
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 800 CHF (Swiss Francs).

Keywords

  • long noncoding rna
  • embryogenesis
  • cell differentiation
  • tissue homeostasis
  • disease
  • histone modifying complexes
  • nuclear structure organization
  • gene regulation
  • rna/protein complexes

 

 

Published Papers (1 paper)

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Review

Open AccessReview Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA
Genes 2015, 6(3), 484-499; doi:10.3390/genes6030484
Received: 29 May 2015 / Revised: 19 June 2015 / Accepted: 26 June 2015 / Published: 7 July 2015
Cited by 14 | PDF Full-text (432 KB) | HTML Full-text | XML Full-text
Abstract
It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and thereby offer
[...] Read more.
It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and thereby offer novel opportunities for diagnosis and therapy. Of particular interest in this regard is GAS5 lncRNA, which is down-regulated in multiple cancers, with expression levels related to both clinico-pathological characteristics and patient prognosis. Functional studies have further shown that GAS5 lncRNA both inhibits the proliferation and promotes the apoptosis of multiple cell types, and that together these cellular mechanisms of action are likely to form the basis of its tumour suppressor action. At the same time, advances have been made in our understanding of the molecular mechanisms of GAS5 lncRNA action in recent years, including riborepression of certain steroid hormone receptors and sequestration of miR-21, impacting key regulatory pathways of cell survival. Overall this accumulating knowledge has the potential to improve both the diagnosis and treatment of cancer, and ultimately patient outcome. Full article
(This article belongs to the Special Issue Long Noncoding RNAs)

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