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Review Collection on Population and Evolutionary Genetics and Genomics
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Review Collection on Population and Evolutionary Genetics and Genomics

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Population and Evolutionary Genetics and Genomics".

Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 1543

Special Issue Editor

Prof. Dr. Nico M. Van Straalen

E-Mail Website
Guest Editor
Department of Ecological Science, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
Interests: evolution; molecular ecology; ecological genomics; zoology; toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, titled “Review Collection on Population and Evolutionary Genetics and Genomics”, covers studies of genetic diversity and evolution in all organisms. We welcome the submission of studies using any kind of genetic markers as long as they provide interesting novel insights into the biology of the organism or into more general population genetics and evolutionary questions. Studies based on genomic data are particularly welcome. Topics within the scope of this Special Issue include, but are not limited to:

  • Genetic polymorphism;
  • Geographic variation;
  • Gene flow and introgression;
  • Selection in natural populations;
  • Phylogenetics;
  • Metagenomics;
  • Ancient DNA.

We look forward to receiving your contribution to this Special Issue, which will exclusively host review-type papers providing valuable insights into all aspects of population and evolutionary genetics and genomics.

Prof. Dr. Nico M. Van Straalen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Review

13 pages, 3420 KiB  
Review
Nonribosomal Peptide Synthetases in Animals
by Wouter Suring, Dylan Hoogduin, Giang Le Ngoc, Abraham Brouwer, Nico M. van Straalen and Dick Roelofs
Genes 2023, 14(9), 1741; https://doi.org/10.3390/genes14091741 - 30 Aug 2023
Cited by 1 | Viewed by 1270
Abstract
Nonribosomal peptide synthetases (NRPSs) are a class of cytosolic enzymes that synthesize a range of bio-active secondary metabolites including antibiotics and siderophores. They are widespread among both prokaryotes and eukaryotes but are considered rare among animals. Recently, several novel NRPS genes have been [...] Read more.
Nonribosomal peptide synthetases (NRPSs) are a class of cytosolic enzymes that synthesize a range of bio-active secondary metabolites including antibiotics and siderophores. They are widespread among both prokaryotes and eukaryotes but are considered rare among animals. Recently, several novel NRPS genes have been described in nematodes, schistosomes, and arthropods, which led us to investigate how prevalent NRPS genes are in the animal kingdom. We screened 1059 sequenced animal genomes and showed that NRPSs were present in 7 out of the 19 phyla analyzed. A phylogenetic analysis showed that the identified NRPSs form clades distinct from other adenylate-forming enzymes that contain similar domains such as fatty acid synthases. NRPSs show a remarkably scattered distribution over the animal kingdom. They are especially abundant in rotifers and nematodes. In rotifers, we found a large variety of domain architectures and predicted substrates. In the nematode Plectus sambesii, we identified the beta-lactam biosynthesis genes L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine synthetase, isopenicillin N synthase, and deacetoxycephalosporin C synthase that catalyze the formation of beta-lactam antibiotics in fungi and bacteria. These genes are also present in several species of Collembola, but not in other hexapods analyzed so far. In conclusion, our survey showed that NRPS genes are more abundant and widespread in animals than previously known. Full article
(This article belongs to the Special Issue Review Collection on Population and Evolutionary Genetics and Genomics)
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