RNA Modification in Inflammation and Metabolism

Dear Colleagues,

N6-methyladenosine (m6A) methylation, the most prevalent internal RNA modification in mammals, is known to regulate the structure, stability, translation, and function of almost every major class of human RNAs. The m6A RNA modification has been implicated in diverse pathophysiological processes, such as involvement in cell metabolism, proliferation, differentiation, inflammation, and apoptosis, during the development of cardiovascular, metabolic, and neurodegenerative diseases, as well as cancer. Investigating signal transduction pathways or molecular networks underlying the regulation of the m6A RNA modification in pathophysiological processes has been a hot area of research over the past decade. From a mechanistic perspective, the disruption or dysregulation of the m6A RNA modification represents a major event that drives the pathogenesis of complex diseases. This has been consolidated by accumulating evidence provided by the biomedical research communities. For this reason, ‘RNA Modification in Inflammation and Metabolism’ is a timely and necessary topic of discussion for the basic, translational, and clinical research communities.

The important topics in this Special Issue of Epigenomes include but are not limited to the following:

(1) The mechanistic basis and functional significance of m6A RNA modification in inflammatory and metabolic pathways.

(2) RNA modification in the pathogenesis of complex diseases, including but not limited to metabolic syndrome,  cardiovascular disease, autoimmune disease, neurogenerative disease, and cancer.

(3) m6A RNA modification and transcriptome.

(4) The mechanistic links between cellular stress responses and RNA modification.

(5) Interactions between environmental stressors and RNA modification.

(6) m6A RNA modification and viral infection.

(7) Targeting m6A RNA modification for therapeutics.

Prof. Dr. Kezhong Zhang
Dr. Juncheng Wei
Dr. Cristina Espinosa-Diez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• RNA modification
• N6-methyladenosine (m6A) RNA
• Inflammation
• Metabolism
• Stress Response
• Complex Disease