Special Issue "Ionic Liquids in Drug Delivery"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Crystal Engineering".

Deadline for manuscript submissions: closed (31 March 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Sitaram Velaga

Department of Health Sciences, Luleå University of Technology, Luleå, Sweden
Website | E-Mail
Interests: pharmaceutical materials; polymorphs; physical stability; solubility; salts; cocrystals; crystallization; phase diagrams; drug formulation
Guest Editor
Dr. Manishkumar R. Shimpi

Researcher, Chemistry of Interfaces, Luleå University of Technology, SE-971 87, Luleå, Sweden
Website 1 | Website 2 | E-Mail
Interests: pharmaceutical cocrystals; hydrogen bonding; ionic liquids; tribology; nanochemistry

Special Issue Information

Dear Colleagues,

Ionic liquids (ILs) are salts of organic cations and inorganic or organic anions, with low melting points (<100 °C, by definition). In the context of pharmaceutics, ionic liquids belong to a special class of ionic materials that are liquids at ambient temperature and show negligible vapor pressures with a wide range of temperature stabilities. The physical and chemical properties of ILs can be fine-tuned with the appropriate selection of cation and anions. In pharmaceutical sciences, ILs have been investigated as a crystallization media to engineer material properties of active pharmaceutical ingredients (API). Another important and emerging area is API-ionic liquid technology, where the solid API is turned into a liquid at ambient temperatures in order to address solubility or processing problems of APIs in drug products.

This Special Issue on “Ionic Liquids in Drug Delivery” is intended to inform and stimulate on-going and new interdisciplinary research activities on the development and novel applications of ionic liquids in pharmaceutical sciences. We invite regular articles, communications, and reviews covering wide range of topics covering utilization or formation of ionic liquid to improve the physicochemical properties of drug molecules. Examples of a few topics of interest are presented below;

  • Ionic liquids as solvents and/or co-solvents for crystallization and processing pharmaceutical solids, such as in polymorphs, cocrystals, salts: Articles may cover fundamental and experimental studies on the design, characterization and structure–property relationships of a wide range of ILs with potentials in pharmaceutical crystallization. Studies on the role of ILs on nucleation crystal growth, habit and crystal structure will also be of high scientific interest.
  • API-ionic liquids: A wide range of subjects dealing API-ionic liquids would be of high relevance, which include the formation of ionic liquids of diverse classes of APIs and structural insights, characterization, various formulation and drug delivery strategies applied to ILs, pharmacokinetic studies, etc.

We look forward to articles covering your exciting research on Ionic liquids.

Prof. Sitaram Velaga
Dr. Manishkumar Shimpi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessArticle Effect of Ionic Liquids on the Separation of Sucrose Crystals from a Natural Product Using Crystallization Techniques
Crystals 2017, 7(10), 284; https://doi.org/10.3390/cryst7100284
Received: 26 August 2017 / Revised: 18 September 2017 / Accepted: 20 September 2017 / Published: 23 September 2017
Cited by 1 | PDF Full-text (8242 KB) | HTML Full-text | XML Full-text | Supplementary Files
The present work aims to investigate the applicability of ionic liquids (ILs) for natural ingredient crystallization. First, the medicinal plant, namely Angelica gigas Nakai, was extracted using methanol (MeOH) as a solvent. Afterwards, ILs 1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF4), 1-butyl-3-methylimidazolium hexafluorophosphate (BMImPF6
[...] Read more.
The present work aims to investigate the applicability of ionic liquids (ILs) for natural ingredient crystallization. First, the medicinal plant, namely Angelica gigas Nakai, was extracted using methanol (MeOH) as a solvent. Afterwards, ILs 1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF4), 1-butyl-3-methylimidazolium hexafluorophosphate (BMImPF6), 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMImTFSI), 1-allyl-3-ethylim idazolium tetrafluoroborate (AEImBF4), and 1,3-diallyl imidazolium tetrafluoroborate (AAImBF4), in three ratios of 1:1, 1:2, and 1:3 (extraction solution/ILs (v/v)) were used as an anti-solvent to induce crystallization. Crystals were obtained within 8 h and were then identified to be pure crystals of sucrose through nuclear magnetic resonance (1H-NMR) analysis. Moreover, the single-crystal X-ray diffraction (SXD) analysis revealed all recovered crystals have an identical crystal structure and the morphology was monitored using a video microscope. With the application of BMImBF4 and BMImPF6, transformation of sucrose crystal morphology from an elongated hexagon shape to an elongated rectangular shape was observed with respect to the respective concentration increase. Here, all crystals precipitated from BMImBF4 and BMImPF6 were found to possess identical PXRD patterns. However, when BMImTFSI was employed, small rectangular crystals attached to the larger rectangular-shaped crystals due to secondary nucleation and shapeless amorphous forms were observed according to the alteration in the solution to ILs ratio. Accordingly, the ability of ILs as a relevant anti-solvent for the selective crystallization of a single compound from a natural product was assessed through the study. Furthermore, the applicability of ILs as crystal engineering solvents are expected to modify both the solid state and the crystal morphology of natural compounds, which can influence drug manufacturability, dissolution rate, and bioavailability. Full article
(This article belongs to the Special Issue Ionic Liquids in Drug Delivery)

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