Special Issue "Polymorphism of Mechanochemically Synthesized Cocrystals"

A special issue of Crystals (ISSN 2073-4352). This special issue belongs to the section "Crystal Engineering".

Deadline for manuscript submissions: 31 October 2017

Special Issue Editor

Guest Editor
Dr. Franziska Emmerling

Federal Institute for Materials Research and Testing Berlin, Berlin, Germany
Website | E-Mail
Interests: mechanochemistry; polymorphism; cocrystals; metal–organic frameworks; nanoparticles; crystallography; in situ methods

Special Issue Information

Dear Colleagues,

During the last few years, mechanochemistry has emerged as a powerful method to form new structures by application of mechanical energy. In the simplest approach, a mortar and pestle are used to introduce solid transformations. Using automated milling devices, mechanochemical syntheses have become faster and more reliable. Mechanochemistry can produce solid forms, which are different to solution methods, without the need for miscible reactants. Therefore, the mechanochemical approach is now established as a green and efficient route for the formation of cocrystals and their polymorphs. Cocrystals are defined as multicomponent crystalline materials consisting of neutral molecules stabilized by non-covalent interactions, such as hydrogen bonds, π-π stacking, or halogen bonds. The cocrystallization of a compound with a suitable coformer can improve its physiochemical properties, such as solubility or stability, making it attractive for the development of new materials in pharmacy, agriculture, and explosives. The phenomenon of polymorphism is of great interest in academic and industrial research. Although polymorphs usually only differ slightly in energy, properties can change dramatically. Therefore, the control of polymorphism is of huge importance. The addition of liquids and polymers during grinding can influence the outcome of mechanochemical reactions. Mechanistic information is still sparse, making further research in the mechanochemical preparation of polymorphic cocrystals necessary.

Contributions in this Special issue cover, but are not limited to:

  • Mechanochemical syntheses and characterization of cocrystals
  • Transformation and stability of polymorphs
  • Structure/property relationships of cocrystals
  • Control of polymorphism during grinding: the role of solvent/additives in mechanochemical cocrystal formation
  • Prediction and mechanism of cocrystal formations

Dr. Franziska Emmerling
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mechanochemistry
  • Polymorphism
  • Cocrystal

Published Papers

This special issue is now open for submission.

Journal Contact

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