Translation in Cancer Stem Cells Research: Molecular and Cellular Approach

Dear Colleagues,

Cancer stem cells (CSCs), also named tumor initiating cells (TICs), are tumor cells that have in common several characteristics with normal stem cells, such as the capacity for self-renewal and differentiation, as well as the common activation of signalling pathways aimed at maintaining these properties. The great importance of CSCs within bulk tumor is that they are responsible of tumor initiation, progression, metastasis, resistance to treatment and cancer recurrence. Moreover, heterogeneity and interactions of these TICs with other cell types and the tumor microenvironment, in both primary mass and metastatic sites, are essentials for the cancer progression and prognosis in patients. Today, many characteristics and contributions of CSCs to the tumor process are known, but there are still molecular and cellular unknown aspects that are of vital importance for the real translation from bench to bedside in the early diagnosis and effective treatment of cancer. This novel knowledge will allow to have an effective personalized and precision oncology that improve outcomes for a larger number of patients.

This Special issue seeks to expand the knowledge about molecular and cellular aspects related to CSCs focused in the potential translation to clinical arena. In particular, we welcome the submission of contributions dealing with one or more of the following areas related to CSCs:

-Molecular pathways; cell-to-cell communications; CSCs heterogeneity, extracellular matrix remodelling, primary tumor microenvironment, pre-metastatic niche, secretome, interactome and metastasome, cancer resistome, tumor remodelling, extracellular vesicles (exosomes, microvesicles and apoptotic bodies), liquid biopsy, CSCs biomarkers, targeted CSCs therapies, translational research.

Prof. Juan Antonio Marchal Corrales
Dr. Gema Jiménez-González
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Cancer Stem Cells
• CSCs heterogeneity
• Tumor microenvironment
• Tumor remodelling
• Molecular signalling
• Metastasis
• Extracellular vesicles
• Liquid biopsy
• Targeted therapy
• Traslacional research