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Highlights of the 3rd Meeting of the French Society for...
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Highlights of the 3rd Meeting of the French Society for Stem Cell Research (FSSCR)

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 7963

Special Issue Editors

Dr. Pierre Savatier

E-Mail Website
Guest Editor
INSERM U1208, Stem Cell and Brain Research Institute, 18 avenue Doyen Lepine, 69500 Bron, France
Interests: pluripotent stem cells; embryo chimeras; cycle regulation
Dr. Cécile Martinat

E-Mail Website
Guest Editor
INSERM UEVE UMR 861, I-STEM, Association Française des Myopathies, 28 Rue Henri Desbruères, 91100 Corbeil Essonnes, France
Interests: human pluripotent stem cells; differentiation; disease modeling; drug screening; cell therapy
Dr. Thierry Jaffredo

E-Mail Website
Guest Editor
Institut de Biologie Paris Seine, CNRS UMR7622, INSERM U1156, Sorbonne Université, 9 Quai St Bernard, CEDEX 05, 75252 Paris, France
Interests: development; stem cells; hematopoietic stem cells; niche cells; stem cell niche interactions; high troughput approaches

Special Issue Information

Dear Colleagues,

The 3rd annual meeting of the French Society for Stem Cell Research (FSSCR) will be held in Lyon on November 18 and 19, 2019. It will be organized around four sessions: “Gastruloids and Blastoids”, “Organoids”, “Stem Cells at the Single Cell Level”, and “Epigenetics and Aging”. All participants wishing to submit an Abstract at any of these four sessions, whether for a poster or a short presentation, have the opportunity to also submit an article for publication in this Special Issue of Cells. This article can be a review or an original manuscript.

Dr. Thierry Jaffredo
Dr. Pierre Savatier
Dr. Cécile Martinat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

22 pages, 6983 KiB  
Article
FAK Deficiency in Bone Marrow Stromal Cells Alters Their Homeostasis and Drives Abnormal Proliferation and Differentiation of Haematopoietic Stem Cells
by Yuenv Wu, Lydia Campos, Elisabeth Daguenet, Zhiguo He, Tiphanie Picot, Emmanuelle Tavernier-Tardy, Gilbert Soglu, Denis Guyotat and Carmen-Mariana Aanei
Cells 2020, 9(3), 646; https://doi.org/10.3390/cells9030646 - 06 Mar 2020
Cited by 4 | Viewed by 2884
Abstract
Emerging evidence indicates that in myelodysplastic syndromes (MDS), the bone marrow (BM) microenvironment may also contribute to the ineffective, malignant haematopoiesis in addition to the intrinsic abnormalities of haematopoietic stem precursor cells (HSPCs). The BM microenvironment influences malignant haematopoiesis through indirect mechanisms, but [...] Read more.
Emerging evidence indicates that in myelodysplastic syndromes (MDS), the bone marrow (BM) microenvironment may also contribute to the ineffective, malignant haematopoiesis in addition to the intrinsic abnormalities of haematopoietic stem precursor cells (HSPCs). The BM microenvironment influences malignant haematopoiesis through indirect mechanisms, but the processes by which the BM microenvironment directly contributes to MDS initiation and progression have not yet been elucidated. Our previous data showed that BM-derived stromal cells (BMSCs) from MDS patients have an abnormal expression of focal adhesion kinase (FAK). In this study, we characterise the morpho-phenotypic features and the functional alterations of BMSCs from MDS patients and in FAK knock-downed HS-5 cells. The decreased expression of FAK or its phosphorylated form in BMSCs from low-risk (LR) MDS directly correlates with BMSCs’ functional deficiency and is associated with a reduced level of haemoglobin. The downregulation of FAK in HS-5 cells alters their morphology, proliferation, and differentiation capabilities and impairs the expression of several adhesion molecules. In addition, we examine the CD34+ healthy donor (HD)-derived HSPCs’ properties when co-cultured with FAK-deficient BMSCs. Both abnormal proliferation and the impaired erythroid differentiation capacity of HD-HSPCs were observed. Together, these results demonstrate that stromal adhesion mechanisms mediated by FAK are crucial for regulating HSPCs’ homeostasis. Full article
(This article belongs to the Special Issue Highlights of the 3rd Meeting of the French Society for Stem Cell Research (FSSCR))
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24 pages, 6830 KiB  
Article
NOTO Transcription Factor Directs Human Induced Pluripotent Stem Cell-Derived Mesendoderm Progenitors to a Notochordal Fate
by Pauline Colombier, Boris Halgand, Claire Chédeville, Caroline Chariau, Valentin François-Campion, Stéphanie Kilens, Nicolas Vedrenne, Johann Clouet, Laurent David, Jérôme Guicheux and Anne Camus
Cells 2020, 9(2), 509; https://doi.org/10.3390/cells9020509 - 24 Feb 2020
Cited by 20 | Viewed by 4587
Abstract
The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology has great potential in delaying the [...] Read more.
The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology has great potential in delaying the onset of disc degeneration or as a regenerative-cell source for disc repair. Using human pluripotent stem cells, we developed a two-step method to generate a stable NC-like population with a distinct molecular signature. Time-course analysis of lineage-specific markers shows that WNT pathway activation and transfection of the notochord-related transcription factor NOTO are sufficient to induce high levels of mesendoderm progenitors and favour their commitment toward the notochordal lineage instead of paraxial and lateral mesodermal or endodermal lineages. This study results in the identification of NOTO-regulated genes including some that are found expressed in human healthy disc tissue and highlights NOTO function in coordinating the gene network to human notochord differentiation. Full article
(This article belongs to the Special Issue Highlights of the 3rd Meeting of the French Society for Stem Cell Research (FSSCR))
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