Metabolic Syndrome in Cancer

Dear Colleagues,

The complexity of the epidemiological evidence around the relationship between obesity and cancer reflects the wide interplay among metabolic pathways involved in cancer development, progression, and pharmacological responsiveness. To date, a plethora of circulating factors and molecular alterations, whereby obesity can lead to carcinogenesis, have been detected. Despite this, the primarily relevant mechanisms are not well understood. Since it is very clear that obesity is one modifiable risk factor for tumorigenesis, lifestyle interventions addressed at reducing adiposity, including dietary changes and physical activity, play a pivotal role in cancer prevention.

This research topic focuses on the metabolic pathways responsible for carcinogenesis, their epidemiology and prevention strategies, the modulation of therapeutic approaches, the role of dietary and lifestyle interventions, and predictions of prognosis, with the aim of assessing at-risk populations and proposing new prevention strategies.

Prof. Dr. Antonio Moschetta
Dr. Lucilla Crudele
Guest Editors

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• metabolic diseases
• cancer
• obesity
• microbiome
• nutrition
• carcinogenesis