Updates on Epigenetics of Brain Tumor

Dear Colleagues,

Primary malignant brain tumors can affect people of any age, including children, and are usually highly aggressive as well as heterogeneous cancers. Currently, epigenetic alterations are a well-established hallmark of these cancers, though there is still a critical need to gain a deeper understanding of their specific roles during tumorigenesis. This Special Issue, dedicated to the epigenetics of malignant brain tumors, with a special focus on glioblastoma multiforme, will highlight the causes and functional consequences of a dysregulated epigenetic landscape in these frequently fatal cancers, covering both basic and more clinical aspects. Original experimental and clinical studies, as well as reviews, studying the plethora of altered epigenetic mechanisms (such as DNA methylation/hydroxymethylation and histone post-translational modifications) in cancerous brain tumors are invited. Finally, how epigenetic players could represent clinical targets, in addition to how their modulation could inform novel therapeutic strategies, and future challenges to overcome for spurring their translation into clinical oncology will also be discussed.

Dr. Virginia López Martínez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• epigenetics
• glioma
• omics analyses
• 5-hydroxymethylcytosine
• DNA methylation
• histones
• chromatin signatures
• biomarkers
• precision medicine