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Brain Sciences
Special Issues
Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges
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Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: closed (30 December 2019) | Viewed by 17934

Special Issue Editors

Dr. Samar S. Ayache

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Guest Editor
1. EA4391 Excitabilité Nerveuse & Therapeutique, Université Paris Est Créteil, 94010 Creteil, France
2. Neurophysiology Department, Henri Mondor Hospital, 94010 Creteil, France
Interests: multiple sclerosis; MS fatigue; MS pain; neurophysiology; evoked potentials; electroencephalography; non-invasive brain stimulation
Special Issues, Collections and Topics in MDPI journals
Dr. Moussa Antoine Chalah

E-Mail Website
Guest Editor
1. Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, 94000 Créteil, France
2. Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, 94000 Créteil, France
Interests: neurosciences; multiple sclerosis; Transcranial Magnetic Stimulation (TMS); Transcranial Direct- Current Stimulation (tDCS)
Special Issues, Collections and Topics in MDPI journals
Dr. Simran Sidhu

E-Mail Website
Guest Editor
School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
Interests: exercise; fatigue and training; physical activity; human neurophysiology; neuroplasticity; non invasive brain stimulation

Special Issue Information

Dear Colleagues,

Fatigue is a frequent and devastating complaint in patients with multiple sclerosis (MS). It affects up to 90% of patients at some point during their disease course and can drastically alter their quality of life. To date, the underlying mechanisms of MS fatigue remain to be clarified. Its evaluation mainly relies on subjective scales which renders the symptom difficult to be described by patients or characterized by physicians. The available approved therapeutic options yield unsatisfactory outcomes in a large number of cases and are challenged by several side effects. Alternative therapies have been explored in this context but their effects remain to be confirmed in large scale studies. Facing all these limitations, more research is needed in an attempt to improve the clinical characterization of the symptom, understand its pathophysiology and optimize its management.

For all these reasons, this Special Issue focuses on, but is not limited to, reviews and original studies addressing fatigue pathophysiology, evaluation and management. This includes works addressing the clinical, neuropsychological, physiological, molecular and imaging substrates of MS fatigue. Studies applying pharmaceutical or alternative interventions are of great interest.

Dr. Samar S. Ayache
Dr. Moussa A. Chalah
Dr. Simranjit Sidhu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multiple sclerosis (MS)
  • MS fatigue
  • Pathophysiology
  • Mechanisms
  • Treatment
  • Therapy
  • Evaluation

Published Papers (3 papers)

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Editorial

Jump to: Research, Review

5 pages, 197 KiB  
Editorial
Fatigue and Affective Manifestations in Multiple Sclerosis—A Cluster Approach
by Samar S. Ayache and Moussa A. Chalah
Brain Sci. 2020, 10(1), 10; https://doi.org/10.3390/brainsci10010010 - 22 Dec 2019
Cited by 20 | Viewed by 2876
Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, characterized by a high prevalence in young people, a drastic impact on the quality of life, and an important economic cost to society [...] Full article
(This article belongs to the Special Issue Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges)

Research

Jump to: Editorial, Review

13 pages, 3847 KiB  
Article
Characterizing Fatigue-Related White Matter Changes in MS: A Proton Magnetic Resonance Spectroscopy Study
by Kalyan Yarraguntla, Fen Bao, Samuel Lichtman-Mikol, Sara Razmjou, Carla Santiago-Martinez, Navid Seraji-Bozorgzad, Shitiz Sriwastava and Evanthia Bernitsas
Brain Sci. 2019, 9(5), 122; https://doi.org/10.3390/brainsci9050122 - 27 May 2019
Cited by 10 | Viewed by 3766
Abstract
Few cross-sectional studies have investigated the correlation between neurochemical changes and multiple sclerosis (MS) fatigue, but little is known on the fatigue-related white matter differences between time points. We aim to investigate the longitudinal neurometabolite profile of white matter in MS fatigue. Forty-eight [...] Read more.
Few cross-sectional studies have investigated the correlation between neurochemical changes and multiple sclerosis (MS) fatigue, but little is known on the fatigue-related white matter differences between time points. We aim to investigate the longitudinal neurometabolite profile of white matter in MS fatigue. Forty-eight relapsing remitting multiple sclerosis (RRMS) patients with an expanded disability status scale (EDSS) ≤ 4 underwent high field 1H-multivoxel magnetic resonance spectroscopy (MRS) at baseline and year 1. Fatigue severity was evaluated by the fatigue severity scale (FSS). Patients were divided into low (LF, FSS ≤ 3), moderate (MF, FSS = 3.1–5), and high fatigue (HF, FSS ≥ 5.1) groups. In a two-way analysis of variance (ANOVA), we observed a decline in the ratio of the sum of N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) to the sum of creatine (Cr) and phosphocreatine (PCr) in the right anterior quadrant (RAQ) and left anterior quadrant (LAQ) of the MRS grid in the HF group at baseline and year 1. This decline was significant when compared with the LF group (p = 0.018 and 0.020). In a one-way ANOVA, the fatigue group effect was significant and the ratio difference in the right posterior quadrant (RPQ) and left posterior quadrant (LPQ) of the HF group was also significant (p = 0.012 and 0.04). Neurochemical changes in the bilateral frontal white matter and possibly parietooccipital areas were noted in the HF group at two different time points. Our findings may shed some light on the pathology of MS fatigue. Full article
(This article belongs to the Special Issue Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges)
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Review

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23 pages, 671 KiB  
Review
Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation
by Stefanie Linnhoff, Marina Fiene, Hans-Jochen Heinze and Tino Zaehle
Brain Sci. 2019, 9(5), 100; https://doi.org/10.3390/brainsci9050100 - 2 May 2019
Cited by 50 | Viewed by 9542
Abstract
Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is still limited. This limitation is already caused by [...] Read more.
Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is still limited. This limitation is already caused by an inconsistent and heterogeneous terminology and assessment of fatigue. In this review, we integrate previous literature on fatigue and propose a unified schema aiming to clarify the fatigue taxonomy. With special focus on cognitive fatigue, we survey the significance of objective behavioral and electrophysiological fatigue parameters and discuss the controversial literature on the relationship between subjective and objective fatigue assessment. As MS-related cognitive fatigue drastically affects quality of life, the development of efficient therapeutic approaches for overcoming cognitive fatigue is of high clinical relevance. In this regard, the reliable and valid assessment of the individual fatigue level by objective parameters is essential for systematic treatment evaluation and optimization. Transcranial electrical stimulation (tES) may offer a unique opportunity to manipulate maladaptive neural activity underlying MS fatigue. Therefore, we discuss evidence for the therapeutic potential of tES on cognitive fatigue in people with MS. Full article
(This article belongs to the Special Issue Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges)
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