Special Issue "FRET-Based Biosensors"

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: 1 November 2018

Special Issue Editor

Guest Editor
Dr. Karl David Wegner

INAC Institute for Nanoscience and Cryogenics; French Alternative Energies and Atomic Energy Commission, CEA-Grenoble, France
Website | E-Mail
Interests: biosensors; FRET; immunoassays; multiplexing; quantum dots; spectroscopy; imaging; nanoparticle synthesis

Special Issue Information

Dear Colleagues,

In the last few decades, Förster resonance energy transfer (FRET) has become an established method for the sensitive detection of various targets in numerous biosensing applications. FRET is a non-radiative energy transfer from an excited donor to an acceptor at a close distance (a few nanometres). The high distance sensitivity makes it a preferred tool for qualitative and quantitative analyses of biological interactions and processes. The utilization of new fluorescent materials, such as semiconductor nanocrystals, upconversion nanoparticles, fluorescent polymers, metal chelates, various noble metal and other nanoparticles, have greatly fostered advancements in the design of biosensors. FRET biosensors combining these robust fluorophores with new sensor designs enabled translation from the utilization of sophisticated benchtop fluorescent spectrometers to simple point-of-care devices for the assessment of biomarkers, drugs, environmental pollution, and for food quality analysis.

In this Special Issue, manuscripts are invited, which are devoted to the application of FRET for designing various types of sensors. Both reviews and original research articles will be published. Reviews should provide a critical overview of the current state-of-the-art in a particular application field, such as in vitro diagnostics, food safety and quality control or environmental pollution. Critical overviews about the use of a specific fluorophores, such as semiconductor nanocrystals or other nanoparticles in FRET-based biosensing applications, are also of interest. Original research papers that present new FRET-based sensor designs and/or fundamental studies with potential relevance to biosensing are also welcome.

Dr. Karl David Wegner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • FRET
  • luminescence
  • nanotechnology
  • nanomaterials
  • fluorescent probes
  • diagnostics
  • bioanalysis
  • point-of-care
  • imaging
  • food safety
  • environmental pollution

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle A DNA-Based Assay for Digoxin Detection
Biosensors 2018, 8(1), 19; https://doi.org/10.3390/bios8010019
Received: 6 February 2018 / Revised: 27 February 2018 / Accepted: 1 March 2018 / Published: 6 March 2018
PDF Full-text (3840 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The most common method for quantifying small-molecule drugs in blood samples is by liquid chromatography in combination with mass spectrometry. Few immuno-based assays are available for the detection of small-molecule drugs in blood. Here we report on a homogeneous assay that enables detection
[...] Read more.
The most common method for quantifying small-molecule drugs in blood samples is by liquid chromatography in combination with mass spectrometry. Few immuno-based assays are available for the detection of small-molecule drugs in blood. Here we report on a homogeneous assay that enables detection of the concentration of digoxin spiked into in a plasma sample. The assay is based on a shift in the equilibrium of a DNA strand displacement competition reaction, and can be performed in 30 min for concentrations above 10 nM. The equilibrium shift occurs upon binding of anti-digoxigenin antibody. As a model, the assay provides a potential alternative to current small-molecule detection methods used for therapeutic drug monitoring. Full article
(This article belongs to the Special Issue FRET-Based Biosensors)
Figures

Figure 1

Back to Top