Skin Stem Cell Therapy: Wound Healing and Regeneration

Dear Colleagues,

Skin wound healing and regeneration are driven by skin-resident stem cells that continuously replenish the epidermis, dermis and skin appendages, and stem cell loss or dysfunction during aging or resulting from systemic disorders significantly impairs cutaneous wound healing or regenerative capacity, with declines in skin elasticity and barrier function, hair loss and dysregulation of immune homeostasis. Nonhealing wounds pose a significant health problem in older patients who often also suffer from chronic systemic disorders. Stem cell therapy carries great promise in the field of regenerative medicine, and our understanding of the precise contributions of various skin-resident stem cell populations to wound healing and regeneration is continuously being refined. Recently, prior limitations concerning the isolation of molecularly defined, pure stem cell populations with established roles in skin homeostasis and regeneration have started to be overcome for the design of rational cell-based strategies for skin regenerative disorders. This Special Issue aims to present cutting-edge research in the fields of skin stem cell biology, skin regeneration and wound healing, with particular attention paid to the design of novel stem cell therapeutic approaches to dermatological disorders.

We cordially invite you to contribute your original research to this Special Issue of Biomolecules.

Sincerely,

Dr. Markus H. Frank
Guest Editor

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