Blood-Compatible Materials: Preparation, Modification and Functionalization: 2nd Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 325

Special Issue Editor

Key Laboratory of Polymeric Material Design and Synthesis for Biomedical Function, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren−Ai Road, Suzhou 215123, China
Interests: blood-compatible materials; heparin mimetic materials; protein–surface interactions; cell–surface interactions; surface modification and biofunctionalization of materials for microfluidic chips
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Special Issue Information

Dear Colleagues,

Blood-compatible materials possess properties that enable their use in contact with blood. They are widely required in a variety of medical devices. Their range of applications includes vascular access products, extracorporeal blood treatments, and cardiovascular implantable medical devices. Despite more than 70 years of continuous efforts, materials that are ideally compatible with blood in all aspects have not been obtained. All medical devices that come into contact the blood stream are susceptible to thrombotic complications, even in the presence of anticoagulants. With an ever-increasing use of blood-contacting devices, there is an urgent need to develop truly blood-compatible materials.

This Special Issue of Biomimetic, entitled “Blood-Compatible Materials: Preparation, Modification and Functionalization”, calls for contributions from researchers in all realms of blood-compatible materials. This subject is inherently interdisciplinary and thus we welcome theoretical, experimental, and review contributions from physicists, chemists, biologists, material scientists, engineers, and all those who are engaged and interested in this fast-growing field.

Potential topics include, but are not limited to, the following:

  • Antifouling materials;
  • Bioactive materials;
  • Biomimetic materials;
  • Blood–material interactions;
  • Computer simulation for design of blood-compatible materials;
  • Characterization tools/protocols to evaluate blood compatibility.

Dr. Xiaoli Liu
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • blood compatibility
  • thrombosis
  • surface modification
  • protein adsorption
  • antifouling
  • cell behavior
  • biomimetic

Published Papers (1 paper)

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Research

32 pages, 7435 KiB  
Article
Aminolysis-Based Zwitterionic Immobilization on Polyethersulfone Membranes for Enhanced Hemocompatibility: Experimental, Computational, and Ex Vivo Investigations
by Arash Mollahosseini, Jumanah Bahig, Ahmed Shoker and Amira Abdelrasoul
Biomimetics 2024, 9(6), 320; https://doi.org/10.3390/biomimetics9060320 - 27 May 2024
Viewed by 227
Abstract
Dialysis membranes are not hemocompatible with human blood, as the patients are suffering from the blood–membrane interactions’ side effects. Zwitterionic structures have shown improved hemocompatibility; however, their complicated synthesis hinders their commercialization. The goal of the study is to achieve fast functionalization for [...] Read more.
Dialysis membranes are not hemocompatible with human blood, as the patients are suffering from the blood–membrane interactions’ side effects. Zwitterionic structures have shown improved hemocompatibility; however, their complicated synthesis hinders their commercialization. The goal of the study is to achieve fast functionalization for carboxybetaine and sulfobetaine zwitterionic immobilization on PES membranes while comparing the stability and the targeted hemocompatibility. The chemical modification approach is based on an aminolysis reaction. Characterization, computational simulations, and clinical analysis were conducted to study the modified membranes. Atomic force microscopy (AFM) patterns showed a lower mean roughness for carboxybetaine-modified (6.3 nm) and sulfobetaine-modified (7.7 nm) membranes compared to the neat membrane (52.61 nm). The pore size of the membranes was reduced from values above 50 nm for the neat PES to values between 2 and 50 nm for zwitterionized membranes, using Brunauer–Emmett–Teller (BET) analysis. More hydrophilic surfaces led to a growth equilibrium water content (EWC) of nearly 6% for carboxybetaine and 10% for sulfobetaine-modified membranes. Differential scanning calorimetry (DSC) measurements were 12% and 16% stable water for carboxybetaine- and sulfobetaine-modified membranes, respectively. Sulfobetaine membranes showed better compatibility with blood with respect to C5a, IL-1a, and IL-6 biomarkers. Aminolysis-based zwitterionization was found to be suitable for the improvement of hemodialysis membranes. The approach introduced in this paper could be used to modify the current dialysis membranes with minimal change in the production facilities. Full article
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