Biomaterials in Bone Regeneration: Challenges to Guarantee Appropriate Biological Features 2.0
A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetics of Materials and Structures".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 551
Special Issue Editor
Special Issue Information
Dear Colleagues,
The treatment of bone defects remains a significant challenge in need of a chemical solution, despite the many therapeutic options that have been developed like autografts, allografts, and artificial scaffolds. With the development of biomaterials in recent years, biomaterials in the form of 3D‐printed scaffolds have emerged as a powerful tool in bone tissue engineering research, allowing for the creation of scaffolds with precise internal architecture and controlled mechanical and biological properties. The success of these scaffolds depends on the careful selection of materials, printing parameters, and scaffold designs. Tissue-engineered bone grafts aim to create a mechanically strong, biologically viable, and degradable bone graft by combining a three-dimensional porous scaffold with osteoblast or progenitor cells.
Moreover, there is growing interest in utilizing biomimetic electroactive biomaterials that closely mimic and recapitulate the natural electrophysiological microenvironment of healthy bone tissue, providing a favorable and conducive microenvironment to promote osteogenesis and bone regeneration under various pathological conditions.
The current challenges mainly concern ensuring appropriate biological properties for stimulating the adhesion, proliferation, and differentiation of specific cell populations, in addition to the vascularization of the graft. This Special Issue is an opportunity for comparison among authors who have been dealing with these topics and provides a stimulus for young researchers who are entering this fascinating field to provide their contribution and reach for ever more ambitious milestones.
Dr. Berta García-Mira
Guest Editor
Manuscript Submission Information
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Keywords
- bone regeneration
- biomaterials
- tissue engineering
- osteoblast
- mesenchymal stem cells
- 3D bioprinting
- vascularization
- angiogenesis
- osteogenesis
- growth factor
