Special Issue "Anti-inflammatory Activity of Plant Polyphenols"

A special issue of Biomedicines (ISSN 2227-9059).

Deadline for manuscript submissions: 30 September 2018

Special Issue Editors

Guest Editor
Prof. Dr. Mario Dell'Agli

Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Milan, Italy
Website | E-Mail
Phone: +390250318398
Interests: botanicals; plant polyphenols; berries; gastro-intestinal inflammation; skin inflammation; bio-guided fractionation
Guest Editor
Dr. Enrico Sangiovanni

Università degli Studi di Milano, Department of Pharmacological and Biomolecular Sciences, Milan, Italy
Website | E-Mail
Interests: botanicals; gastritis; inflammation; plant extracts; gastrointestinal epithelium

Special Issue Information

Dear Colleagues,

Inflammation is the first body response to infection or injury, and is critical for both innate and adaptive immunity. It can be considered as part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Uncontrolled inflammation often results in chronic diseases, such as gastritis, arthritis, autoimmune disorders, degenerative joint diseases, rheumatisms, atherosclerosis, diabetes, and even cancer. The inflammatory process is characterized by migration of immune cells from blood vessels to the site of inflammation, with massive release of pro-inflammatory mediators, including cytokines, chemokines, prostaglandins, leukotrienes, and oxidative agents.

The search for new strategies, able to interfere with these mechanisms by preventing a prolonged inflammation, would greatly benefit large number of subjects. In this respect, the plant kingdom has developed a multitude of secondary metabolites, many of which are recognized as useful tools for the maintenance of human health. Several botanicals from edible or medicinal plants are widely consumed all over the world for health purposes, as different types of products, including herbal medicinal products, plant food supplements, and functional foods. The purpose of this Special Issue is to collect new findings on the anti-inflammatory activity of polyphenols from plants, as individual compounds or as ingredients of extracts, focusing mostly on their effects on the inhibition of pro-inflammatory mediators and their mechanism of action. Both in vitro and in vivo studies are welcome.

Prof. Dr. Mario Dell'Agli
Dr. Enrico Sangiovanni
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Botanicals
  • Plant polyphenols
  • Anti-inflammatory
  • cytokines
  • transcription factors
  • chemokines
  • pro-inflammatory mediators
  • eicosanoids
  • secondary metabolites

Published Papers (2 papers)

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Research

Open AccessArticle Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy
Biomedicines 2018, 6(2), 48; https://doi.org/10.3390/biomedicines6020048
Received: 16 March 2018 / Revised: 16 April 2018 / Accepted: 19 April 2018 / Published: 23 April 2018
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Abstract
Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo.
[...] Read more.
Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy. Full article
(This article belongs to the Special Issue Anti-inflammatory Activity of Plant Polyphenols)
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Open AccessArticle Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System
Biomedicines 2018, 6(1), 11; https://doi.org/10.3390/biomedicines6010011
Received: 12 December 2017 / Revised: 21 January 2018 / Accepted: 23 January 2018 / Published: 26 January 2018
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Abstract
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or
[...] Read more.
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB), aminopeptidase N (APN) and insulin-regulated aminopeptidase (IRAP). These enzyme activities generate active or inactive angiotensin peptides that alter the ratios between their bioactive forms, regulating several important processes such as the regulation of cardiovascular functions, body water regulation, normal memory consolidation and retrieval, but also cell growth, differentiation and apoptosis or the inflammatory response. We have previously described that the treatment with hydroxytyrosol but not with oleuropein or with the mixture of both compounds led to the significant inhibition of tumor growth in an in vivo glioma model by mechanisms not only related to redox balance. Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFα to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. We found that oleuropein increased all the activities analyzed and promoted a pro-inflammatory status, whereas hydroxytyrosol only modified ASAP and IRAP activities and promotes an anti-inflammatory status. When administrated together, oleuropein overrode the effects of hydroxytyrosol. Our results suggest a role for angiotensin III and angiotensin 1-7 in both tumor growth inhibition and anti-inflammatory response promoted by hydroxytyrosol. Full article
(This article belongs to the Special Issue Anti-inflammatory Activity of Plant Polyphenols)
Figures

Graphical abstract

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