Next Article in Journal
Neural Oscillatory Correlates for Conditioning and Extinction of Fear
Previous Article in Journal
Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
Previous Article in Special Issue
Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessArticle
Biomedicines 2018, 6(2), 48; https://doi.org/10.3390/biomedicines6020048

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

1
Department of Pharmacological and Biomolecular Sciences (DiSFeB), Università degli Studi di Milano, Via Balzaretti, 9-20133 Milan, Italy
2
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
3
EMAN Biodiscoveries Sdn. Bhd., Suite 126, Level 1, EUREKA Complex, University of Science Malaysia (USM), Minden Gelugor 11800, Penang, Malaysia
4
School of Pharmaceutical Sciences, University of Science Malaysia, Minden Gelugor 11800, Penang, Malaysia
5
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada
6
Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincol, NE 68508, USA
7
John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia
8
Centre for Natural Product and Angiogenesis Research/Department of Pharmacology, Faculty of Medicine, Quest International University, Ipoh 30250, Malaysia
*
Authors to whom correspondence should be addressed.
Received: 16 March 2018 / Revised: 16 April 2018 / Accepted: 19 April 2018 / Published: 23 April 2018
(This article belongs to the Special Issue Anti-inflammatory Activity of Plant Polyphenols)
View Full-Text   |   Download PDF [2842 KB, uploaded 3 May 2018]   |  

Abstract

Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy. View Full-Text
Keywords: neuroprotection; Rhus coriaria; linoleic acid; ischemic optic neuropathy; anti-neuroinflammation neuroprotection; Rhus coriaria; linoleic acid; ischemic optic neuropathy; anti-neuroinflammation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Khalilpour, S.; Behnammanesh, G.; Suede, F.; Ezzat, M.O.; Muniandy, J.; Tabana, Y.; Ahamed, M.B.K.; Tamayol, A.; Majid, A.M.S.; Sangiovanni, E.; Dell’Agli, M.; Majid, A.S. Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy. Biomedicines 2018, 6, 48.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biomedicines EISSN 2227-9059 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top