Recent Advances in Biomolecular Radiation Research

Dear colleagues,

Together with surgery and chemotherapy, radiotherapy is part of the standard treatment options for cancer patients. So far, photon radiation is the most frequently used radiotherapy in the clinical setting.

During the last few decades, major advances have been made in our understanding of the mechanisms driving the development of radiotherapy, radiosensitization, and normal tissue protection. A major progress is represented by the further development of particle radiation, especially proton therapy. However, further knowledge is needed to understand how different types of radiation, combination with chemotherapy, and also approaches combining radiotherapy with immunotherapy lead to possible benefits for patients.

This Special Issue addresses these emerging questions. We would like to focus on clinical advances of radiation research but also in particular on studies revealing biomolecular mechanisms which underlie the cellular response to radiation. Here, topics of our SI range from DNA damage response and DNA repair over protein and organelle damage to tissue- and system-wide radiation effects. In particular, we welcome studies focusing on immune response altering effects of radiation.

Gathering more detailed knowledge of the experts in our exciting research field addressing the relationships of molecular alterations, cellular response, and clinic-related outcome offers a great opportunity to promote a better understanding and development of new radiotherapeutic approaches.

Dr. Sebastian Oeck
Dr. Nathalie M. Malewicz
Dr. Adam J. Krysztofiak
Guest Editors

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• radiation
• DNA damage
• DNA repair
• molecular stress response
• genotoxicity
• dosimetry
• radiotherapy
• combination treatment
• molecular biology