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Applied Sciences
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Antioxidants in Natural Products III
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Antioxidants in Natural Products III

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 4465

Special Issue Editors

Prof. Dr. Antony C. Calokerinos

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Guest Editor
Laboratory of Analytical Chemistry, Department of Chemistry, School of Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece
Interests: analytical chemistry; method validation; antioxidants; natural products
Special Issues, Collections and Topics in MDPI journals
Dr. Charalampos Proestos

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Guest Editor
Food Chemistry Laboratory, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Interests: antioxidants; bioactive compounds; essential oils; plant extracts; food chemistry; food analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Mustafa Bener

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Guest Editor
Department of Chemistry, Faculty of Science, Istanbul University, 34126 Istanbul, Turkey
Interests: analytical method development for antioxidants and other food constituents; optical sensors; nanosensors; food chemistry; natural products chemistry; phytochemicals; antioxidants
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Vassilia J. Sinanoglou

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Guest Editor
Instrumental Food Analysis, Laboratory of Chemistry, Analysis & Design of Food Processes, Department of Food Science and Technology, Food Sciences School, University of West Attica, 12210 Egaleo, Greece
Interests: instrumental food analysis (chromatography, mass spectrometry, spectroscopy) analytical methods development; natural antioxidants extraction from agricultural side-streams; biomolecular structure identification; organoleptic properties (color and texture) measurement; image analysis of foods; chemometrics and application of statistical analysis for the classification and monitoring of the nutritional value of food products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Awareness of the importance of the antioxidants in food, beverages, and so on has increased significantly during the last decade. The food and beverage industry is utilizing antioxidants from natural sources to replace synthetic antioxidants because of the negative health consequences and beliefs associated with the latter. Natural antioxidants, such as polyphenols, carotenoids, and vitamin C, exhibit a plethora of biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis, and anticancer effects. Much scientific research has been devoted to the evaluation of the antioxidant activity of natural products, such as olive oil, fruits, and vegetables, as well as the extraction, isolation, and characterization of antioxidant compounds from medicinal plants, spices, and marine sources. Much research has also been devoted to the recovery of antioxidants from olive mill waste, winery waste, and other wastes, as well as their use for the authentication (e.g., geographical origin, organic–non-organic) of foods and natural products by means of chemometrics.

The aim of this Special Issue, entitled “Antioxidants in Natural Products III”, aims to collect recent scientific research on the discovery of new antioxidants from all kinds of foods, beverages, and natural products, as well as their uses for human benefit, and to critically present available and emerging analytical methods for the measurement of the antioxidant activity and other quality parameters of natural products.

Prof. Dr. Antony C. Calokerinos
Dr. Charalampos Proestos
Dr. Mustafa Bener
Prof. Dr. Vassilia J. Sinanoglou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • natural products
  • medicinal plants
  • spices
  • marine sources
  • olive mill waste
  • winery waste
  • antioxidant activity
  • quality parameters
  • analytical methods for antioxidants
  • authentication

Published Papers (3 papers)

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Research

12 pages, 2482 KiB  
Article
Antioxidant and Anti-Inflammatory Effects of Agarum cribrosum Extract and Its Fractions in LPS-Induced RAW 264.7 Macrophages
by Mi-Bo Kim, Hyeju Lee, Terrence Vance and Sang Gil Lee
Appl. Sci. 2023, 13(18), 10048; https://doi.org/10.3390/app131810048 - 06 Sep 2023
Cited by 1 | Viewed by 856
Abstract
Excessive oxidative stress and chronic inflammation are implicated in the pathogenesis of chronic inflammation diseases. The purpose of this study was to determine whether the antioxidant and anti-inflammatory effects of Busan-grown Agarum cribrosum ethanol extract (ACE) and its organic solvent five fractions are [...] Read more.
Excessive oxidative stress and chronic inflammation are implicated in the pathogenesis of chronic inflammation diseases. The purpose of this study was to determine whether the antioxidant and anti-inflammatory effects of Busan-grown Agarum cribrosum ethanol extract (ACE) and its organic solvent five fractions are exhibited in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. ACE and its five fractions from ACE evaluated the total antioxidant activity and the effect of pro-inflammatory cytokines and antioxidant genes expression in LPS-induced RAW 264.7 macrophages. ACE and its ethyl acetate (EtOAc) fraction showed a high total phenolic content and total antioxidant capacity by decreasing free radicals scavenging activity. ACE and its EtOAc fraction significantly repressed LPS-induced tumor necrosis factor α and interleukin-1β gene expression. Additionally, ACE and its EtOAc fraction significantly diminished the LPS-stimulated gene expression of inducible nitric oxide synthase and cyclooxygenase 2 genes with a concomitant decrease in their protein levels in the macrophages. The gene expression of NADPH oxidase 2 was significantly abolished by ACE and its EtOAc fraction in LPS-induced macrophages, while other antioxidant genes showed minimal effects. The results suggest that ACE and its EtOAc fraction exert inhibitory effects on LPS-stimulated inflammation and oxidative stress in macrophages accompanied by total antioxidant activity. Full article
(This article belongs to the Special Issue Antioxidants in Natural Products III)
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18 pages, 870 KiB  
Article
Antioxidant Activity of the Prunus mahaleb Seed Oil Extracts Using n-Hexane and Petroleum Ether Solvents: In Silico and In Vitro Studies
by Zhawen Noori Hussein, Hoshyar Abdullah Azeez and Twana Salih
Appl. Sci. 2023, 13(13), 7430; https://doi.org/10.3390/app13137430 - 23 Jun 2023
Viewed by 1695
Abstract
Prunus mahaleb L., also known as white mahaleb, and native to the Kurdistan region of Iraq, has significant nutraceutical and therapeutic ingredients. The seeds are rich in conjugated fatty acids with small quantities of cyanogenic glycosides, coumarin derivatives, and flavonoids. The contents of [...] Read more.
Prunus mahaleb L., also known as white mahaleb, and native to the Kurdistan region of Iraq, has significant nutraceutical and therapeutic ingredients. The seeds are rich in conjugated fatty acids with small quantities of cyanogenic glycosides, coumarin derivatives, and flavonoids. The contents of the seeds were extracted with the Soxhlet apparatus using n-hexane and petroleum ether solvents, separately. Gas chromatography-mass spectrometry (GC-MS) was used to recognize the chemical composition of the compounds. The radical scavenging activity was performed for the total extracts from n-hexane and petroleum ether solvents using 2,2-diphenyl-1 picrylhydrazyl (DPPH) assay and compared with quercetin as a positive control. Furthermore, molecular docking was performed for the identified compounds against five enzymes that have main roles in intracellular oxidation. Afterwards, drug-like properties and bioactivity predictions were applied for all compounds using Molinspiration software. The results showed four phthalate derivatives, six saturated fatty acids (SFAs), five monounsaturated fatty acids (MUFAs), and three polyunsaturated fatty acids (PUFAs). The n-hexane extract showed competitive antioxidant activity with quercetin and the in-silico studies suggested a notable antioxidant activity of the seed oil contents with apparent drug-likeness properties. Further studies are required to separate the extracts, then perform in vitro antioxidant activity on the compounds. Full article
(This article belongs to the Special Issue Antioxidants in Natural Products III)
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15 pages, 3610 KiB  
Article
Cytotoxic and Antioxidant Activity of a Chemically Characterized Extract of Smilax aspera Leaves and Stems
by Eleni Kakouri, Kyriaki Hatziagapiou, Charalabos Kanakis, Olti Nikola, George I. Lambrou, Panayiotis Trigas, Christina Kanaka-Gantenbein and Petros A. Tarantilis
Appl. Sci. 2023, 13(8), 4784; https://doi.org/10.3390/app13084784 - 11 Apr 2023
Cited by 2 | Viewed by 1341
Abstract
The present study identifies the phytochemical profile of a hydroalcoholic extract derived from Smilax aspera leaves and stems, estimates its antioxidant capacity and evaluates its cytotoxic activity against glioblastoma (A172 cell line) and rhabdomyosarcoma (TE671 cell line). Chemical analysis of leaves and stems [...] Read more.
The present study identifies the phytochemical profile of a hydroalcoholic extract derived from Smilax aspera leaves and stems, estimates its antioxidant capacity and evaluates its cytotoxic activity against glioblastoma (A172 cell line) and rhabdomyosarcoma (TE671 cell line). Chemical analysis of leaves and stems was performed with liquid chromatography analysis combined with a quadrupole time-of-flight high-resolution mass spectrometry (LC/Q-TOF/HRMS). The antioxidant activity of the extract was evaluated with the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and the 2,2′-azinobis[3-ethylbenzthiazoline-6-acid)] (ABTS) assays. Cell viability was examined using the alamar blue assay. Most of the compounds tentatively identified belonged to the flavonoids family, with rutin being the most abundant, followed by luteolin. The extract showed potent antioxidant activity which corresponded to 13.9 ± 1.91 μg/mL (DPPH assay) and 6.27 ± 1.7 μg/mL (ABTS assay), expressed as IC50 values. The extract inhibited the proliferation of cancer cells. The lowest IC50 value for A172 cells was observed 48 h after treatment and was calculated at 0.482 ± 0.98 mg/mL while for the TE671 cell line the lowest IC50 value was 0.629 ± 1.31 mg/mL, calculated 72 h after treatment. Considering the high biological value of flavonoids as health defense promoters, S. aspera leaves and stems can be an important natural source to consider as they may provide important health benefits. Full article
(This article belongs to the Special Issue Antioxidants in Natural Products III)
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