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Applied Sciences
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Diagnosis and Treatment of Dry Eye Disease
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Diagnosis and Treatment of Dry Eye Disease

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (10 July 2022) | Viewed by 9750

Special Issue Editor

Prof. Dr. Sang Beom Han

E-Mail Website
Guest Editor
Department of Ophthalmology, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon 24289, Republic of Korea
Interests: cornea; cataract; dry eye disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although dry eye disease is one of the most common diseases and is frequently encountered in ophthalmologic clinics, its diagnosis and treatment are often difficult because of its multifactorial nature and lack of correlation between the symptoms and signs of the disease. Variability in diagnostic criteria for dry eye disease and unsatisfactory reliability of the conventional diagnostic tests have also made the diagnosis of the disease difficult. However, recent development of new diagnostic devices has enabled more precise and reproducible evaluation of the ocular surface and tear film. Development of novel drugs is also expected to be helpful for the treatment of the disease.

In this Special Issue, any papers regarding the diagnosis and treatment of dry eye disease are welcome. Papers on the diagnosis and treatment of ocular surface diseases mimicking or associated with dry eye disease are welcome.

Prof. Dr. Sang Beom Han
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anterior segment
  • dry eye disease
  • diagnosis
  • ocular surface disease
  • treatment

Published Papers (3 papers)

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Research

11 pages, 301 KiB  
Article
Dry Eye Disease and Vitamins: A Narrative Literature Review
by Joon Young Hyon and Sang Beom Han
Appl. Sci. 2022, 12(9), 4567; https://doi.org/10.3390/app12094567 - 30 Apr 2022
Cited by 4 | Viewed by 5859
Abstract
Dry eye disease (DED) is a major public health problem worldwide that seriously impairs the quality of life, reduces work productivity, and poses significant economic burden. In DED, tear film instability or hyperosmolarity activates a self-perpetuating vicious cycle that may aggravate ocular surface [...] Read more.
Dry eye disease (DED) is a major public health problem worldwide that seriously impairs the quality of life, reduces work productivity, and poses significant economic burden. In DED, tear film instability or hyperosmolarity activates a self-perpetuating vicious cycle that may aggravate ocular surface inflammation and damage. Thus, treatment approaches should focus on interrupting this cycle and ameliorating inflammation. In addition to anti-inflammatory medications, such as corticosteroids, cyclosporine, and lifitegrast, nutrients with anti-inflammatory and anti-oxidative properties may also be effective for the treatment of DED. Evidence indicates that vitamin deficiencies may be associated with an increased risk of DED and that vitamin supplementation can be an effective treatment for DED. In the present review, we introduce the results of clinical and experimental studies on the association between vitamin deficiencies and DED. The potential efficacy of systemic and topical supplementation in the treatment of DED is also discussed. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Dry Eye Disease)
18 pages, 2829 KiB  
Article
MIC-1 Antlerogenic Stem Cells Homogenate from Cervus elaphus Accelerate Corneal Burn Reepithelization in Rabbits
by Wojciech Dziewiszek, Marek Bochnia, Dorota Szumny, Stanisław Dzimira, Adam Szeląg and Antoni Szumny
Appl. Sci. 2022, 12(5), 2468; https://doi.org/10.3390/app12052468 - 26 Feb 2022
Cited by 1 | Viewed by 1402
Abstract
Deer antler is the only mammalian organ that can fully grow back once lost from its pedicle. Antler regeneration is a stem cell-based process. Therefore, antlers probably offer the most pertinent model for studying organ regeneration in mammals. Evaluation of the effect of [...] Read more.
Deer antler is the only mammalian organ that can fully grow back once lost from its pedicle. Antler regeneration is a stem cell-based process. Therefore, antlers probably offer the most pertinent model for studying organ regeneration in mammals. Evaluation of the effect of deer antler stem cells on the healing of superficial and deep rabbit corneal wounds was performed. Thirty-six New Zealeand White rabbits were used in this study in superficial and deep denaturation models, and corneal erosion was performed with n-heptanol placed on the cornea for 30 and NaOH for 90 s. Antler stem cells in drop formulation with hyaluronate was used. As a control, sodium hyaluronate in the superficial model and protein-free calf blood dialysate (Solcoseryl) in the deep model were administered. In superficial corneal damage, a reduction in the area of the damaged cornea was observed from day 3 of the experiment to an adequate level: 45% in the test group and 52% in the control group relative to the baseline damage (100%). Between days 3 and 7, on average, a smaller lesion area was observed in the group receiving antler stem cells. The use of antler stem cells has resulted in a marked improvement in cornea clarity. According to the 5-point scale of corneal opacity evaluation, where 1 is completely clear and 5 is completely opaque, the first statistically significant changes were observed after 4 weeks of treatment: 3.0 in the study group, 4.1 in the control with Solcoseryl, and 4.4 in the control group. After 9 weeks, these values were, 2.5, 3.8, and 4.1, respectively. The present preliminary study shows the promising results of antlerogenic stem cells of Cervus elaphus topically applied for the treatment of corneal injury. A deeper understanding of the developmental mechanisms involved in antler renewal can be useful for controlling regeneration cornea processes. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Dry Eye Disease)
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11 pages, 480 KiB  
Article
Changes in Tear Osmolarity and Matrix Metalloproteinase-9 Relative to Ocular Discomfort after Femtosecond Laser-Assisted Cataract Surgery
by Kyu Sang Eah, Hun Lee, Jae Yong Kim and Hungwon Tchah
Appl. Sci. 2021, 11(24), 11878; https://doi.org/10.3390/app112411878 - 14 Dec 2021
Cited by 1 | Viewed by 1799
Abstract
The aim of this study was to evaluate the changes in tear osmolarity and matrix metalloproteinase-9 (MMP-9) and their relationships with ocular discomfort in patients after femtosecond laser-assisted cataract surgery (FLACS). This retrospective observational case series reviewed medical records of 51 eyes of [...] Read more.
The aim of this study was to evaluate the changes in tear osmolarity and matrix metalloproteinase-9 (MMP-9) and their relationships with ocular discomfort in patients after femtosecond laser-assisted cataract surgery (FLACS). This retrospective observational case series reviewed medical records of 51 eyes of 51 patients who underwent FLACS. Tear osmolarity and MMP-9 were evaluated preoperatively and at 1 day, 1 week, and 1 month postoperatively. Tear osmolarity ≥ 310 mOsm/L and MMP-9 ≥ trace positive were defined as abnormal results. The ocular surface disease index (OSDI) was evaluated preoperatively and postoperatively at 1 month. Tear osmolarity level and the number of eyes with abnormal tear osmolarity results did not change significantly up to 1 month after surgery. MMP-9 level and the number of eyes with abnormal MMP-9 results increased at 1-day postoperatively and then decreased at 1-month postoperatively (all p < 0.001). Among the OSDI subscales, ocular discomfort was aggravated (p < 0.001) but the visual function score improved at 1 month postoperatively (p < 0.001). Ocular discomfort aggravated after FLACS without an increase in either tear osmolarity or MMP-9. Ocular discomfort which patients commonly experience after FLACS may be due to etiology other than development or aggravation of dry eye disease. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Dry Eye Disease)
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