Detection and Imaging of Tumor Cells in a 3D Environment
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3667
Special Issue Editors
Interests: tumor biology; immunology; imaging; digital holographic cytometry; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Interests: biomedical laboratory science/technology; cell molecular biology
Interests: tumor biology; biochemistry and genetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Three-dimensional (3D) models of cell cultures constitute highly important preclinical approaches to study cancer in vitro. The most common 3D models include spheroids and organoids. Other approaches include air-liquid interface (ALI) cultures of epithelia of the human body, i.e., the skin, the intestine, and the lung. The 3D models offer more physiological micro environment by maintaining the in vivo tumor cell type composition and tissue architecture. Cells grown in 3D resemble in vivo conditions more closely also in terms of cell protein, gene expression, and cell metabolism. Moreover, 3D models are more amenable to low cost and high-throughput research needs, and it may be possible to individualize patient care through prospective modeling of drug sensitivity in patient-derived 3D cultures. The purpose of this Special Issue is to attract publications that report on complex cancer cell cultures in vitro with the aim to better understand applications such as treatment, detection, drug delivery, and protocol development for 3D cultures.
Prof. Dr. Anette Gjörloff Wingren
Dr. Anna Gustafsson
Dr. Michal Masarik
Guest Editors
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Keywords
- 3D cell cultures
- cancer
- detection
- imaging
- microscopy
- tumor microenvironment
- tumor metabolism