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Applied Sciences
Special Issues
Biomedical Applications of Bioactive Ingredients from Natural Products
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Biomedical Applications of Bioactive Ingredients from Natural Products

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 918

Special Issue Editors

Dr. Georgia Eirini Deligiannidou

E-Mail Website
Guest Editor
1. Pharmacoepidemiology Laboratory, Medical School, Democritus University of Thrace, Greece
2. Department of Clinical, Pharmaceutical & Biological Sciences, University of Hertfordshire, UK
3. Department of Clinical Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece
Interests: pharmacoepidemiology; neuropsychopharmacology; addiction medicine; psychoactive substances; ethnopharmacology; natural substances; herbal medicine
Dr. Christos Kontogiorgis

E-Mail Website
Guest Editor
Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, 68100 Alexandroupoli, Greece
Interests: public health; hygiene; medicinal chemistry; natural products; antioxidants; pharmacoepidemiology; nutritional epidemiology; structure-activity relationships; drug utilisation; risk minimization and communication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural products have historically made a large contribution to the advancement of drug discovery. Bioactive ingredients and their structural analogues play key roles in preventing and treating non-communicable and chronic diseases, a function that has accelerated scientific interest. Modern methods of evaluation and manipulation of bioactive ingredients from natural products have enabled a better understanding of their mechanisms of action and a clearer view of their potential in medicinal applications.

In this Special Issue, we closely consider the recently developed perspectives on the biomedical applications of bioactive ingredients and their structural analogues from natural products.

A particular focus of this Special Issue will be to summarize the recent technological developments that have enabled natural product-based drug discovery, highlight potential applications in the prevention and treatment of pathological conditions, discuss key challenges in identifying and establishing biological actions, and communicate the opportunities that stem from current research.

Dr. Georgia Eirini Deligiannidou
Dr. Christos Kontogiorgis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • pure compounds
  • encapsulation
  • antioxidant
  • anti-inflammatory
  • nanoparticles
  • bioactive compounds
  • in vitro
  • in vivo

Published Papers (1 paper)

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Research

8 pages, 636 KiB  
Communication
Determination of Sesquiterpenic Acids with Sedative Properties in Extracts of Medicinal Lavender (Lavandula angustifolia Mill.)
by Michalina Adaszyńska-Skwirzyńska, Małgorzata Dzięcioł, Mateusz Bucław, Danuta Majewska and Danuta Szczerbińska
Appl. Sci. 2024, 14(2), 554; https://doi.org/10.3390/app14020554 - 8 Jan 2024
Viewed by 670
Abstract
Plant raw materials with a calming effect on the nervous system are increasingly used in modern phytotherapy. Lavender belongs to this group of plants, due to the content of essential oil with known therapeutic properties and other phytoconstituents that can be responsible for [...] Read more.
Plant raw materials with a calming effect on the nervous system are increasingly used in modern phytotherapy. Lavender belongs to this group of plants, due to the content of essential oil with known therapeutic properties and other phytoconstituents that can be responsible for the sedative effect. Our studies confirmed the presence of sesquiterpenic acids characterized by sedative activity in lavender extracts. The contents of valerenic acid and acetoxyvalerenic acids in flowers and leafy stalks of two various Lavandula angustifolia cultivars—‘Blue River’ and ‘Ellagance Purple’—were determined. Analyses of methanolic extracts performed using the HPLC method showed that content of these sesquiterpenic acids varied with the cultivars and the morphological parts of the plant. The amount of acetoxyvalerenic acid was significantly higher than the amount of valerenic acid. In the ‘Blue River’ cultivar, higher levels of both compounds characterized by sedative properties were found. The content of valerenic acid in flowers ranged from 0.50 mg/100 g d.m. in the ‘Ellagance Purple’ cultivar to 1.75 mg/100 g d.m. in the ‘Blue River’ cultivar. In turn, leafy stalks contained 0.81 mg/100 g d.m. of valerenic acid in the ‘Ellagance Purple’ cultivar and 1.16 mg/100 g d.m. in the ‘Blue River’ cultivar. Interestingly, the ‘Blue River’ cultivar contained about 10 times more acetoxyvalerenic acid (65.80 mg/100 g d.m.) in flowers and four times more acetoxyvalerenic acid in leafy stalks (50.1 mg/100 g d.m.), in comparison with the ‘Ellagance Purple’ cultivar. The higher content of valerenic and acetoxyvalerenic acids in the flowers and leafy stalks of the ‘Blue River’ lavender cultivar can be important for its possible medical applications. Full article
(This article belongs to the Special Issue Biomedical Applications of Bioactive Ingredients from Natural Products)
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