Plant Flavonoids in Cancer Chemoprevention
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (30 June 2016)
Special Issue Information
Dear Colleagues,
Carcinogenesis is a multistage process that involves a series of events comprising of genetic and epigenetic changes leading to the initiation, promotion and progression of cancer. Chemoprevention is referred to as the use of nontoxic natural compounds, synthetic chemicals or their combinations to intervene in multistage carcinogenesis. Chemoprevention through diet modification, i.e., increased consumption of plant-based food, has emerged as a most promising and realistic approach to reduce the risk of cancer. Flavonoids are naturally occurring polyphenols that are ubiquitous in plant-based food such as fruits, vegetables, teas as well as in most medicinal plants. Over 10,000 flavonoids have been characterized over the last few decades. Flavonoids comprise of several sub-classes including flavonols, flavan-3-ols, anthocyanins, flavonones, flavones, isoflavones and proanthocyanidins. Identification of most efficacious plant flavonoids and understanding of the molecular basis of how flavonoids contribute to the chemoprevention including protection against DNA damage caused by various carcinogenic factors is important in developing effective cancer chemopreventive strategies.
This Special Issue will publish both reviews and original research papers on the role of plant flavonoids in cancer chemoprevention. The molecular mechanisms associated with flavonoids as cancer prevention agents, as well as anti-cancer therapeutic effects of flavonoids, will also be included.
Prof. H.P. Vasantha Rupasinghe
Guest Editor
Manuscript Submission Information
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Keywords
- flavonoids
- cancer
- antioxidants
- chemoprevention
- cytoprotection
- carcinogenesis
- detoxification of procarcinogens
- oxidative DNA damage
- DNA damage signaling
- DNA repair
- cell cycle checkpoint arrest
- apoptosis
- mechanisms of action
- structure-function relationship
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